Thrombotic thrombocytopenic purpura associated with interferon therapy in a HIV and HCV co-infected woman

被引：3

作者：

Michaux, C. ^{[1
]}

Randrianasolo, D. ^{[1
]}

Vandenhende, M. -A. ^{[1
]}

Hessamfar, M. ^{[1
]}

Morlat, P. ^{[1
]}

Bonnet, F. ^{[1
]}

机构：

[1] CHU Bordeaux, Hop St Andre, Serv Med Interne & Malad Infect, F-33075 Bordeaux, France

来源：

REVUE DE MEDECINE INTERNE | 2013年 / 34卷 / 12期

关键词：

Thrombotic thrombocytopenic purpura; Interferon; CHRONIC HEPATITIS-C; PATIENT;

D O I：

10.1016/j.revmed.2013.03.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction. - Causes of acquired thrombotic thrombocytopenic purpura (UP) are multiple and rarely iatrogenic. Case report. - A 40-year-old, HIV and hepatitis C virus co-infected woman was treated with interferon and ribavirine and developed a lTP confirmed by the presence of anti-ADAMTS 13 antibodies. The outcome was favourable when treatment was discontinued and rituximab infusion administered. Conclusion. - The occurrence of anemia and thrombocytopenia in patients treated with interferon and ribavirine is not always related to direct toxicities of these treatments. The ADAMS 13 testing may help the clinician to diagnose iatrogenic acquired TM. (C) 2013 Societe nationale francaise de medecine interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.

引用

页码：773 / 775

页数：3

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