The Potential Therapeutic Applications of Olfactory Ensheathing Cells in Regenerative Medicine

被引：23

作者：

Chou, Ruey-Hwang ^{[1
,2
]}

Lu, Cheng-You ^{[3
,4
]}

Wei-Lee ^{[3
,4
]}

Fan, Jia-Rong ^{[2
,4
]}

Yu, Yung-Luen ^{[1
]}

Shyu, Woei-Cherng ^{[3
,4
,5
]}

机构：

[1] China Med Univ, Grad Inst Canc Biol, Ctr Mol Med, Taichung, Taiwan

[2] Asia Univ, Dept Biotechnol, Taichung, Taiwan

[3] China Med Univ & Hosp, Ctr Neuropsychiat, Taichung, Taiwan

[4] China Med Univ & Hosp, Translat Med Res Ctr, Taichung, Taiwan

[5] China Med Univ, Grad Inst Immunol, Taichung, Taiwan

来源：

CELL TRANSPLANTATION | 2014年 / 23卷 / 4-5期

关键词：

Olfactory ensheathing cells (OECs); Neuronal injury; Regenerative medicine; NERVE GROWTH-FACTOR; SPINAL-CORD-INJURY; IN-VITRO; N-CAM; FUNCTIONAL RECOVERY; NEUROTROPHIC FACTOR; ADHESION MOLECULES; AXON REGENERATION; LAMINA-PROPRIA; ADULT-MOUSE;

D O I：

10.3727/096368914X678508

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Olfactory ensheathing cells (OECs) are unique glia cells restricted to the primary olfactory system including the olfactory mucosa, olfactory nerve, and the outer nerve layer of the olfactory bulb. OECs guide growing olfactory axons from the neurons of the nasal cavity olfactory mucosa to the olfactory bulb to connect both the peripheral nervous system (PNS) and central nervous system (CNS). Based on these specialized abilities of OECs, transplantation of OECs to injury sites has been widely investigated for their potential therapeutic applications in neural repair in different injuries. In this article, we reviewed the properties of OECs and their roles in olfactory regeneration and in treatment of different injuries including spinal cord injury, PNS injury, and stroke and neurodegenerative diseases.

引用

页码：567 / 571

页数：5

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