Obesity: The Fat Tissue Disease Version of Cancer

被引:14
|
作者
Boubertakh, Besma [1 ,2 ]
Silvestri, Cristoforo [1 ,2 ]
Di Marzo, Vincenzo [1 ,2 ,3 ,4 ,5 ]
机构
[1] Univ Laval, Ctr Rech, Inst Univ Cardiol & Pneumol Quebec, Dept Med,Fac Med, Quebec City, PQ G1V 0A6, Canada
[2] Univ Laval, Canada Excellence Res Chair Microbiome Endocannab, Quebec City, PQ G1V 0A6, Canada
[3] Consiglio Nazl Ric CNR, Inst Biomol Chem, Endocannabinoid Res Grp, I-80078 Pozzuoli, Italy
[4] Consiglio Nazl Ric Italy, Joint Int Unit, Chem & Biomol Res Microbiome & Its Impact Metab H, I-80078 Pozzuoli, Italy
[5] Univ Laval Canada, Joint Int Unit, Chem & Biomol Res Microbiome & Its Impact Metab H, I-80078 Pozzuoli, Italy
基金
加拿大自然科学与工程研究理事会; 加拿大健康研究院;
关键词
obesity; disease; cancer; white adipose tissue; cell growth; cell proliferation; metastasis; angiogenesis; recurrence; gut microbiome; MECHANISMS LINKING OBESITY; ADIPOSE-TISSUE; GUT MICROBIOTA; TUMOR MICROENVIRONMENT; INSULIN-RESISTANCE; SUDDEN-DEATH; INFLAMMATION; RISK; ANGIOGENESIS; PROGRESSION;
D O I
10.3390/cells11121872
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Obesity is a disease with high potential for fatality. It perfectly fits the disease definition, as cancer does. This is because it damages body structure and functions, both mechanically and biologically, and alters physical, mental, and social health. In addition, it shares many common morbid characteristics with the most feared disease, cancer. For example, it is influenced by a sophisticated interaction between a person's genetics, the environment, and an increasing number of other backgrounds. Furthermore, it displays abnormal cell growth and proliferation events, only limited to white fat, resulting in adipose tissue taking up an increasing amount of space within the body. This occurs through fat "metastases" and via altered signaling that further aggravates the pathology of obesity by inducing ubiquitous dishomeostasis. These metastases can be made graver by angiogenesis, which might boost diseased tissue growth. More common features with cancer include its progressive escalation through different levels of severity and its possibility of re-onset after recovery. Despite all these similarities with cancer, obesity is substantially less agitating for most people. Thus, the ideas proposed herein could have utility to sensitize the public opinion about the hard reality of obesity. This is increasingly needed, as the obesity pandemic has waged a fierce war against our bodies and society in general, while there is still doubt about whether it is a real disease or not. Hence, raising public consciousness to properly face health issues is crucial to improving our health instead of gaining weight unhealthily. It is obviously illogical to fight cancer extremely seriously on the one hand and to consider dying with obesity as self-inflicted on the other. In fact, obesity merits a top position among the most lethal diseases besides cancer.
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页数:16
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