Pituitary adenylate cyclase-activating polypeptide induces hyperthermia in the rat

被引：24

作者：

Pataki, I ^{[1
]}

Adamik, A ^{[1
]}

Jászberényi, M ^{[1
]}

Mácsai, M ^{[1
]}

Telegdy, G ^{[1
]}

机构：

[1] Albert Szent Gyorgyi Med Univ, Dept Pathophysiol, MTA, SZOTE Beurohumoral Res Grp, H-6701 Szeged, Hungary

来源：

NEUROPHARMACOLOGY | 2000年 / 39卷 / 07期

基金：

匈牙利科学研究基金会;

关键词：

hyperthermia; PACAP; rat; noraminophenazone;

D O I：

10.1016/S0028-3908(99)00209-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of centrally administered pituitary adenylate cyclase-activating polypeptide (PACAP-38) on body temperature were investigated in rats. Intracerebroventricular (i.c.v.) administration of PACAP-38 in doses of 500 and 1000 ng induced a dose-related elevation in colon temperature 2, 3, 4, 5 and 6 h after injection. The i.c.v. pretreatment of the animals with different dilutions of PACAP-38 antiserum prevented the development of hyperthermia in PACAP-38-treated animals, whereas PACAP-38 antiserum alone did not modify the colon temperature. An intramuscular injection of noraminophenazone (a cyclooxygenase inhibitor) abolished the PACAP-38-induced hyperthermia. Our data indicate that PACAP may induce hyperthermia via the central nervous system, and this hyperthermic effect may be mediated via a cyclooxygenase-involved pathway. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1303 / 1308

页数：6

共 33 条

[1] Identification of VIP/PACAP receptors on rat astrocytes using antisense oligodeoxynucleotides [J].