Polymorphism of dopamine receptors and transporter genes in neuropsychiatric diseases

被引：25

作者：

Fujiwara, Y

Yamaguchi, K

Tanaka, Y

Tomita, H

Shiro, Y

Kashihara, K

Sato, K

Kuroda, S

机构：

[1] OKAYAMA UNIV,SCH MED,DEPT NEUROPSYCHIAT,OKAYAMA 700,JAPAN

[2] OKAYAMA UNIV,SCH MED,DEPT NEUROL,OKAYAMA 700,JAPAN

[3] NATL SANATORIUM MINAMIOKAYAMA HOSP,CLIN RES INST,OKAYAMA,JAPAN

来源：

EUROPEAN NEUROLOGY | 1997年 / 38卷

关键词：

dopamine receptor subtype; dopamine transporter; schizophrenia; DNA polymorphism;

D O I：

10.1159/000113436

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The advances made in studies on the molecular biology of the dopamine transporter (DAT) and receptors (D1, D2, D3, D4 and D5) are reviewed, and their pharmacological characteristics and the relationship between polymorphic variations of these human proteins and neuropsychiatric disorders are discussed. Data from four studies on the variants of the D2 receptor gene (Ser(311)-->Cys), BalI polymorphism in D3, 48-base repeat polymorphism in D4, and 40-base repeat polymorphism in the DAT gene in patients with schizophrenia, mood disorder, neurological disease and controls are reported.

引用

页码：6 / 10

页数：5

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