Lysosomotropic agents and cysteine protease inhibitors inhibit scrapie-associated prion protein accumulation

被引：273

作者：

Doh-Ura, K

Iwaki, T

Caughey, B

机构：

[1] Kyushu Univ, Dept Neuropathol, Inst Neurol, Grad Sch Med Sci,Higashi Ku, Fukuoka 8128582, Japan

[2] NIAID, Persistent Viral Dis Lab, NIH, Hamilton, MT 59840 USA

来源：

JOURNAL OF VIROLOGY | 2000年 / 74卷 / 10期

关键词：

D O I：

10.1128/JVI.74.10.4894-4897.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We report that lysosomotropic agents and cysteine protease inhibitors inhibited protease resistant prion protein accumulation in scrapie-infected neuroblastoma cells. The inhibition occurred without either apparent effects on normal prion protein biosynthesis or turnover or direct interactions with prion protein molecules. The findings introduce two new classes of inhibitors of the formation of protease-resistant prion protein.

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页码：4894 / 4897

页数：4

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