All-diamond functional surface micro-electrode arrays for brain-slice neural analysis

被引：12

作者：

Vahidpour, Farnoosh ^{[1
]}

Curley, Lowry ^{[2
]}

Biro, Istvan ^{[2
]}

McDonald, Matthew ^{[1
,3
]}

Croux, Dieter ^{[1
]}

Pobedinskas, Paulius ^{[1
]}

Haenen, Ken ^{[1
,3
]}

Giugliano, Michele ^{[2
,3
,4
,5
]}

Zivcova, Zuzana Vlckova ^{[6
]}

Kavan, Ladislav ^{[6
]}

Nesladek, Milos ^{[1
,3
]}

机构：

[1] Hasselt Univ, Inst Mat Res IMO, Hasselt, Belgium

[2] Univ Antwerp, Dept Biomed Sci, Theoret Neurobiol & Neuroengn Lab, Antwerp, Belgium

[3] IMEC VZW, IMOMEC, Leuven, Belgium

[4] Swiss Fed Inst Technol Lausanne, Brain Mind Inst, Lausanne, Switzerland

[5] Univ Sheffield, Dept Comp Sci, Sheffield, S Yorkshire, England

[6] J Heyrovsky Inst Phys Chem AS CR, Vvi, Dept Elect Mat, Prague, Czech Republic

来源：

PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE | 2017年 / 214卷 / 02期

基金：

比利时弗兰德研究基金会;

关键词：

impedance spectroscopy; microelectrode arrays; surface termination; DOPED DIAMOND; RECORDINGS;

D O I：

10.1002/pssa.201532347

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Diamond-based microelectrode arrays were fabricated by using nanocrystalline diamond as an insulating layer and conductive boron-doped in order to used them for analysis of brain cortical slices. MEA surface is solely composed of diamond, exposed to the cells. The impedance measurements showed negligible cross-talk between neighbouring diamond microelectrodes. Local field potentials related to neural signals were then successfully recorded from pharmacologically disinhibited rat cortical tissue slices, mechanically coupled on the surface of the MEA. The background signal level of the diamond MEAs was found to be lower than commercial Pt-based MEAs, under identical measurement conditions.

引用

页数：8

共 30 条

[1]

Allen M., 1994, CLIN MAT, V17, P6605

[2] A diamond-based biosensor for the recording of neuronal activity [J].