Neuroendocrine gene polymorphisms and susceptibility to juvenile idiopathic arthritis

被引：12

作者：

Donn, RP ^{[1
]}

Farhan, A ^{[1
]}

Stevans, A ^{[1
]}

Ramanan, A ^{[1
]}

Ollier, WER ^{[1
]}

Thomson, W ^{[1
]}

机构：

[1] Arthrit Res Campaign Epidemiol Unit, Manchester M13 9PT, Lancs, England

来源：

RHEUMATOLOGY | 2002年 / 41卷 / 08期

关键词：

neuroendocrine; polymorphisms; juvenile idiopathic arthritis;

D O I：

10.1093/rheumatology/41.8.930

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. To investigate the involvement of neuroendocrine candidate genes in the aetiopathogenesis of juvenile idiopathic arthritis (JIA). Methods. Single-nucleotide polymorphisms and intragenic microsatellite markers within five neuroendocrine candidate genes (CRH, CBG, CYP19, ESR1, PRL) were investigated in 463 clinically characterized UK Caucasian JIA patients and a panel of 276 unrelated, healthy UK Caucasian controls. Results. None of the polymorphisms investigated showed any statistically significant associations with JIA. Conclusions. The lack of association with polymorphisins of these neuroendocrine genes suggests that they are not involved in susceptibility to JIA.

引用

页码：930 / 936

页数：7

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