A Multisite, Randomized Controlled Clinical Trial of Computerized Cognitive Remediation Therapy for Schizophrenia

被引:39
作者
Gomar, Jesus J. [1 ,2 ,3 ]
Valls, Elia [1 ]
Radua, Joaquim [1 ,2 ,4 ]
Mareca, Celia [5 ]
Tristany, Josep [6 ]
del Olmo, Francisco [7 ]
Rebolleda-Gil, Carlos [8 ]
Janez-Alvarez, Maria
de Alvaro, Francisco J. [9 ]
Ovejero, Maria R. [10 ]
Llorente, Ana [11 ]
Teixido, Cristina [5 ]
Donaire, Ana M. [6 ]
Garcia-Laredo, Eduardo [7 ]
Lazcanoiturburu, Andrea [8 ]
Granell, Luis [9 ]
de Pablo Mozo, Cristina [10 ]
Perez-Hernandez, Monica [11 ]
Moreno-Alcazar, Ana [1 ,2 ]
Pomarol-Clotet, Edith [1 ,2 ]
McKenna, Peter J. [1 ,2 ]
机构
[1] FIDMAG Hermanas Hosp Res Fdn, Barcelona, Spain
[2] CIBERSAM, Madrid, Spain
[3] Litwin Zucker Res Ctr, Feinstein Inst Med Res, Manhasset, NY USA
[4] Kings Coll London, Inst Psychiat, Dept Psychosis Studies, London WC2R 2LS, England
[5] Psicoclin Mare de Deu Merce, Barcelona, Spain
[6] Hosp Sagrat Cor Martorell, Barcelona, Spain
[7] Clin San Miguel, Madrid, Spain
[8] Ctr Rehabil Picosocial Aranjuez & Vallecas, Madrid, Spain
[9] Complejo Asistencial Benito Menni, Madrid, Spain
[10] Hosp San Luis, Palencia, Spain
[11] Benito Menni CASM, Barcelona, Spain
关键词
schizophrenia; cognition; neuropsychology; cognitive remediation; NEUROCOGNITIVE DEFICITS; SKILLS ASSESSMENT; QUALITY; ENHANCEMENT; VALIDATION; BATTERY; MEMORY;
D O I
10.1093/schbul/sbv059
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
The effectiveness of cognitive remediation therapy (CRT) for the neuropsychological deficits seen in schizophrenia is supported by meta-analysis. However, a recent methodologically rigorous trial had negative findings. In this study, 130 chronic schizophrenic patients were randomly assigned to computerized CRT, an active computerized control condition (CC) or treatment as usual (TAU). Primary outcome measures were 2 ecologically valid batteries of executive function and memory, rated under blind conditions; other executive and memory tests and a measure of overall cognitive function were also employed. Carer ratings of executive and memory failures in daily life were obtained before and after treatment. Computerized CRT was found to produce improvement on the training tasks, but this did not transfer to gains on the primary outcome measures and most other neuropsychological tests in comparison to either CC or TAU conditions. Nor did the intervention result in benefits on carer ratings of daily life cognitive failures. According to this study, computerized CRT is not effective in schizophrenia. The use of both active and passive CCs suggests that nature of the control group is not an important factor influencing results.
引用
收藏
页码:1387 / 1396
页数:10
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