LncRNA Gm12840 mediates WISP1 to regulate ischemia-reperfusion-induced renal fibrosis by sponging miR-677-5p

被引：12
作者：
Chen, Hongtao [1 ]
Fan, Youling [2 ]
Jing, Huan [3 ]
Tang, Simin [3 ]
Huang, Zhenxing [4 ]
Liao, Meijuan [4 ]
Lin, Sen [4 ]
Zhong, Jiying [4 ]
Zhou, Jun [3 ]
机构：
[1] Guangzhou Med Univ, Guangzhou Peoples Hosp 8, Dept Anesthesiol, 8 Huaying Rd, Guangzhou 510060, Guangdong, Peoples R China
[2] Panyu Cent Hosp, Dept Anesthesiol, 8 Fuyu West Rd, Guangzhou 511400, Guangdong, Peoples R China
[3] Southern Med Univ, Affiliated Hosp 3, Dept Anesthesiol, 183 Zhongshan West Rd, Guangzhou 510630, Guangdong, Peoples R China
[4] First Peoples Hosp Foshan, Dept Anesthesiol, 81 North Lingnan Ave, Foshan 528000, Guangdong, Peoples R China
来源：
EPIGENOMICS | 2020年 / 12卷 / 24期
基金：
中国国家自然科学基金;
关键词：
fibrosis; ischemia; lncRNA; renal; reperfusion; ACUTE KIDNEY INJURY; LONG NONCODING RNAS; BETA-CATENIN; PATHOPHYSIOLOGY; INFLAMMATION; ACTIVATION; MECHANISMS; EXPRESSION; DISEASE; MICE;
D O I：
10.2217/epi-2020-0054
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Aim: We aimed to identify that long noncoding RNAs (lncRNAs) are involved in ischemia-reperfusion (IR)-induced late fibrosis of kidney and may constitute novel therapeutic strategies for acute kidney injury-induced chronic kidney disease. Materials & methods: We performed the mouse model of IR later induced renal fibrosis and analyzed lncRNA profiles using second-generation sequencing during the pathogenesis. Results: The expression levels of 43 lncRNAs and 141 lncRNAs were respectively changed significantly 7 days and 2 weeks after IR treatment. Based on the correlation analysis of the differentially expressed genes, the interaction networks of lncRNAs, miRNAs and mRNA were structured. Conclusion: LncRNA (Gm12840) could act as a sponge for miR-677-5p to mediate fibroblast activation induced by TGF-beta 1 via the WISP1/PKB (Akt) signaling pathway.
引用
收藏
页码：2205 / 2218
页数：14
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