A Role for NF-κB in Organ Specific Cancer and Cancer Stem Cells

被引：92

作者：

Kaltschmidt, Christian ^{[1
,17
]}

Banz-Jansen, Constanze ^{[2
,3
,17
]}

Benhidjeb, Tahar ^{[4
,17
]}

Beshay, Morris ^{[5
,17
]}

Foerster, Christine ^{[6
,17
]}

Greiner, Johannes ^{[1
,17
]}

Hamelmann, Eckard ^{[7
,17
]}

Jorch, Norbert ^{[7
,17
]}

Mertzlufft, Fritz ^{[8
,17
]}

Pfitzenmaier, Jesco ^{[9
,10
,17
]}

Simon, Matthias ^{[11
,17
]}

Esch, Jan Schulte Am ^{[4
,17
]}

Vordemvenne, Thomas ^{[12
,13
,17
]}

Waehnert, Dirk ^{[12
,13
,17
]}

Weissinger, Florian ^{[14
,15
,17
]}

Wilkens, Ludwig ^{[6
,17
]}

Kaltschmidt, Barbara ^{[1
,16
,17
]}

机构：

[1] Bielefeld Univ, Dept Cell Biol, Univ Str 25, D-33615 Bielefeld, Germany

[2] Bethel Fdn, Dept Gynecol & Obstet, Protestant Hosp, Burgsteig 13, D-33617 Bielefeld, Germany

[3] Bethel Fdn, Perinatal Ctr, Protestant Hosp, Burgsteig 13, D-33617 Bielefeld, Germany

[4] Bethel Fdn, Dept Gen & Visceral Surg, Protestant Hosp, Schildescher Str 99, D-33611 Bielefeld, Germany

[5] Bethel Fdn, Dept Thorac Surg & Pneumol, Protestant Hosp, Burgsteig 13, D-33617 Bielefeld, Germany

[6] Bethel Fdn, Inst Pathol, KRH Hosp Nordstadt, Protestant Hosp, Haltenhoffstr 41, D-30167 Hannover, Germany

[7] Bethel Fdn, Childrens Ctr, Protestant Hosp, D-33617 Bielefeld, Germany

[8] Bethel Fdn, Protestant Hosp, Maraweg 21, D-33617 Bielefeld, Germany

[9] Bethel Fdn, Dept Urol, Protestant Hosp, Burgsteig 13, D-33617 Bielefeld, Germany

[10] Bethel Fdn, Ctr Comp Assisted & Robot Urol, Protestant Hosp, Burgsteig 13, D-33617 Bielefeld, Germany

[11] Bethel Fdn, Dept Neurosurg & Epilepsy Surg, Protestant Hosp, Burgsteig 13, D-33617 Bielefeld, Germany

[12] Bethel Fdn, Dept Orthoped, Trauma Surg, Protestant Hosp, Burgsteig 13, D-33617 Bielefeld, Germany

[13] Bethel Fdn, Trauma Ctr, Protestant Hosp, Burgsteig 13, D-33617 Bielefeld, Germany

[14] Bethel Fdn, Dept Hematol Oncol Internal Med Bone Marrow & Ste, Palliat Med, Protestant Hosp, Burgsteig 13, D-33617 Bielefeld, Germany

[15] Bethel Fdn, Tumor Ctr, Protestant Hosp, Burgsteig 13, D-33617 Bielefeld, Germany

[16] Bielefeld Univ, Mol Neurobiol, Univ Str 25, D-33615 Bielefeld, Germany

[17] FBMB, Forsch Verbund BioMed Bielefeld, Maraweg 21, D-33617 Bielefeld, Germany

来源：

CANCERS | 2019年 / 11卷 / 05期

关键词：

cancer stem cells; NF-kappa B; glioblastoma multiforme; pediatric cancer; ovarian cancer; multiple myeloma; lung cancer; colon cancer; prostate cancer; bone cancer; EPITHELIAL-MESENCHYMAL TRANSITION; TOTAL MESORECTAL EXCISION; TUMOR-INITIATING CELLS; ACUTE MYELOID-LEUKEMIA; OVARIAN-CANCER; COLORECTAL-CANCER; C-REL; CYTOREDUCTIVE SURGERY; LUNG-CANCER; OPEN-LABEL;

D O I：

10.3390/cancers11050655

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer stem cells (CSCs) account for tumor initiation, invasiveness, metastasis, and recurrence in a broad range of human cancers. Although being a key player in cancer development and progression by stimulating proliferation and metastasis and preventing apoptosis, the role of the transcription factor NF-kappa B in cancer stem cells is still underestimated. In the present review, we will evaluate the role of NF-kappa B in CSCs of glioblastoma multiforme, ovarian cancer, multiple myeloma, lung cancer, colon cancer, prostate cancer, as well as cancer of the bone. Next to summarizing current knowledge regarding the presence and contribution of CSCs to the respective types of cancer, we will emphasize NF-kappa B-mediated signaling pathways directly involved in maintaining characteristics of cancer stem cells associated to tumor progression. Here, we will also focus on the status of NF-kappa B-activity predominantly in CSC populations and the tumor mass. Genetic alterations leading to NF-kappa B activity in glioblastoma, ependymoma, and multiple myeloma will be discussed.

引用

页数：22

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