The calcium/NFAT pathway: role in development and function of regulatory T cells

被引：65

作者：

Oh-hora, Masatsugu ^{[1
]}

Rao, Anjana ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Pathol, Immune Dis Inst, Boston, MA 02115 USA

来源：

MICROBES AND INFECTION | 2009年 / 11卷 / 05期

关键词：

Calcium; Foxp3; Stim1; CA2+ STORE DEPLETION; CRAC CHANNEL; PLASMA-MEMBRANE; SENSOR STIM1; LYMPHOCYTE-ACTIVATION; AUTOIMMUNE ARTHRITIS; PORE SUBUNIT; MICE LACKING; B-CELLS; FOXP3;

D O I：

10.1016/j.micinf.2009.04.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Calcium signals are essential for diverse cellular functions in the immune system. Sustained Ca(2+) entry is necessary for complete and long-lasting activation of calcineurin/NFAT pathways. A growing number of studies have emphasized that Ca(2+)/Calcineurin/NFAT pathway is crucial for both development and function of regulatory T cells. (C) 2009 Elsevier Masson SAS. All rights reserved.

引用

页码：612 / 619

页数：8

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