microRNAs Novel components in a muscle gene regulatory network

被引：15

作者：

Wang, Huating ^{[2
]}

Sun, Hao ^{[3
]}

Guttridge, Denis C. ^{[1
,2
]}

机构：

[1] Ohio State Univ, Coll Med, Human Canc Genet Program, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA

[2] Ohio State Univ, Arthur G James Comprehens Canc Ctr, Columbus, OH 43210 USA

[3] Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA

来源：

CELL CYCLE | 2009年 / 8卷 / 12期

关键词：

microRNA; development; myogenesis; muscle; miR-29; SKELETAL MYOGENESIS; ENZYME DICER; EXPRESSION; MORPHOGENESIS; BIOGENESIS; MIR-206; TARGETS; DIFFERENTIATION; TRANSCRIPTION; CANCER;

D O I：

10.4161/cc.8.12.8851

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the post-transcriptional level via translational inhibition or mRNA degradation. Emerging evidence supports that miRNAs play critical roles in skeletal and cardiac muscle, as both muscle-specific and non-muscle-specific miRNAs are required for the development and differentiation of these tissues. Their interactions with myogenic factors also integrate miRNAs into a complex regulatory network underlying myogenesis. Furthermore, their dysregulation and associated pathologies suggest that miRNA-based therapies may be effective in treating muscle-related disorders.

引用

页码：1833 / 1837

页数：5

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