Effects of beraprost sodium on renal function and inflammatory factors of rats with diabetic nephropathy

被引：15
作者：
Guan, J. [1 ,2 ]
Long, L. [1 ]
Chen, Y. -Q. [1 ]
Yin, Y. [1 ]
Li, L. [1 ]
Zhang, C. -X. [1 ]
Deng, L. [1 ]
Tian, L. -H. [1 ]
机构：
[1] North Sichuan Med Coll, Affiliated Hosp, Nanchong, Sichuan, Peoples R China
[2] North Sichuan Med Coll, Nursing Sch, Nanchong, Sichuan, Peoples R China
来源：
GENETICS AND MOLECULAR RESEARCH | 2014年 / 13卷 / 02期
关键词：
Beraprost sodium; Diabetic nephropathy; Renal function; Inflammatory factors; OXIDATIVE STRESS; HYPERGLYCEMIA; PROSTACYCLIN; ANALOG; DAMAGE;
D O I：
10.4238/2014.June.9.1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Beraprost sodium (BPS) is a prostaglandin analogue. We investigated its effects on rats with diabetic nephropathy. There were 20 rats each in the normal control group (NC), the diabetic nephropathy group (DN), and the BPS treatment group. The rats in DN and BPS groups were given a high-fat diet combined with low-dose streptozotocin intraperitoneal injections. The rats in the BPS group were given daily 0.6 mg/kg intraperitoneal injections of this drug. After 8 weeks, blood glucose, 24-h UAlb, Cr, BUN, hs-CRP, and IL-6 levels increased significantly in the DN group compared with the NC group; however, the body mass was significantly reduced in the DN group compared with the NC group. Blood glucose, urine output, 24-h UAlb, Cr, hs-CRP, and IL-6 levels were significantly lower in the BPS group than in the DN group; the body mass was significantly greater in the DN group. Therefore, we concluded that BPS can improve renal function and protect the kidneys of DN rats by reducing oxidative stress and generation of inflammatory cytokines; it also decreases urinary protein excretion of rats with diabetic nephropathy.
引用
收藏
页码：4154 / 4158
页数：5
相关论文
共 10 条
[1]   The pathobiology of diabetic complications - A unifying mechanism [J].
Brownlee, M .
DIABETES, 2005, 54 (06) :1615-1625
[2]   Acute hyperglycemia and oxidative stress: Direct cause and effect? [J].
Choi, Siu-Wai ;
Benzie, Iris F. F. ;
Ma, Shuk-Woon ;
Strain, J. J. ;
Hannigan, Bernadette M. .
FREE RADICAL BIOLOGY AND MEDICINE, 2008, 44 (07) :1217-1231
[3]  
Gryglewski RJ, 2008, PHARMACOL REP, V60, P3
[4]   Tipping the Balance: the Pathophysiology of Obesity and Type 2 Diabetes Mellitus [J].
McKenney, Rachel L. ;
Short, Daniel K. .
SURGICAL CLINICS OF NORTH AMERICA, 2011, 91 (06) :1139-+
[5]   Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage [J].
Nishikawa, T ;
Edelstein, D ;
Du, XL ;
Yamagishi, S ;
Matsumura, T ;
Kaneda, Y ;
Yorek, MA ;
Beebe, D ;
Oates, PJ ;
Hammes, HP ;
Giardino, I ;
Brownlee, M .
NATURE, 2000, 404 (6779) :787-790
[6]   Estimation of renal function in patients with diabetes [J].
Rigalleau, V. ;
Beauvieu, M. -C. ;
Gonzalez, C. ;
Raffaitin, C. ;
Lasseur, C. ;
Combe, C. ;
Chauveau, P. ;
De la Faille, R. ;
Rigothier, C. ;
Barthe, N. ;
Gin, H. .
DIABETES & METABOLISM, 2011, 37 (05) :359-366
[7]   Action of pelargonidin on hyperglycemia and oxidative damage in diabetic rats: Implication for glycation-induced hemoglobin modification [J].
Roy, Moumita ;
Sen, Subhrojit ;
Chakraborti, Abhay Sankar .
LIFE SCIENCES, 2008, 82 (21-22) :1102-1110
[8]   The Prostacyclin Analog Beraprost Sodium Ameliorates Characteristics of Metabolic Syndrome in Obese Zucker (Fatty) Rats [J].
Sato, Nahoko ;
Kaneko, Masayuki ;
Tamura, Mitsutaka ;
Kurumatani, Hajimu .
DIABETES, 2010, 59 (04) :1092-1100
[9]   Oxidative Stress and Diabetic Kidney Disease [J].
Stanton, Robert C. .
CURRENT DIABETES REPORTS, 2011, 11 (04) :330-336
[10]   Amelioration of Diabetic Nephropathy in OLETF Rats by Prostaglandin I2 Analog, Beraprost Sodium [J].
Watanabe, Maho ;
Nakashima, Hitoshi ;
Mochizuki, Shizue ;
Abe, Yasuhiro ;
Ishimura, Atsunori ;
Ito, Kenji ;
Fukushima, Takao ;
Miyake, Katsuhisa ;
Ogahara, Satoru ;
Saito, Takao .
AMERICAN JOURNAL OF NEPHROLOGY, 2009, 30 (01) :1-11
1