Isolation and identification of a cis-C8-diol-ester of okadaic acid from Dinophysis acuta in New Zealand

被引：38
作者：
Miles, Christopher O.
Wilkins, Alistair L.
Hawkes, Allan D.
Jensen, Dwayne J.
Cooney, Janine M.
Larsen, Kristofer
Petersen, Dirk
Rise, Frode
Beuzenberg, Veronica
MacKenzie, A. Lincoln
机构：
[1] AgRes, Ruakura Res Ctr, Hamilton, New Zealand
[2] Natl Vet Inst, N-0033 Oslo, Norway
[3] Univ Waikato, Dept Chem, Hamilton, New Zealand
[4] HortRes Ltd, Ruakura Res Ctr, Hamilton, New Zealand
[5] Univ Oslo, Dept Chem, N-0315 Oslo, Norway
[6] Cawthron Inst, Nelson, New Zealand
来源：
TOXICON | 2006年 / 48卷 / 02期
关键词：
okadaic acid; diol ester; Dinophysis; hydrolysis; metabolism; NMR; LC-MS;
D O I：
10.1016/j.toxicon.2006.04.018
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A cis-isomer of a C-8-diol ester of okadaic acid (1) was isolated during large-scale purification of pectenotoxins (PTXs) from extracts of Dinophysis acuta collected from the west coast of South Island, New Zealand. The compound was identified by NMR spectroscopic and liquid chromatography-mass spectrometry (LC-MS) studies, and is the first reported cis-isomer of an okadaic acid C-8-diol-ester identified in Dinophysis. The more abundant trans-C-8-diot ester of okadaic acid (2) isolated from the same Dinophysis extract was rapidly hydrolyzed to okadaic acid in vitro by the supernatant from green-lipped mussel hepatopancreas. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：195 / 203
页数：9
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