Molecular mechanisms of trehalose in modulating glucose homeostasis in diabetes

被引：48

作者：

Yaribeygi, Habib ^{[1
]}

Yaribeygi, Alijan ^{[2
]}

Sathyapalan, Thozhukat ^{[3
]}

Sahebkar, Amirhossein ^{[4
,5
,6
]}

机构：

[1] Semnan Univ Med Sci, Res Ctr Physiol, Semnan, Iran

[2] Shahid Beheshti Univ Med Sci, Chron Kidney Dis Res Ctr, Tehran, Iran

[3] Univ Hull, Hull York Med Sch, Dept Acad Diabet Endocrinol & Metab, Kingston Upon Hull HU3 2JZ, N Humberside, England

[4] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Razavi Khorasan, Iran

[5] Mashhad Univ Med Sci, Neurogen Inflammat Res Ctr, Mashhad, Razavi Khorasan, Iran

[6] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Razavi Khorasan, Iran

来源：

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS | 2019年 / 13卷 / 03期

关键词：

Diabetes mellitus; Trehalose; Oxidative stress; Glucose; Homeostasis; PREVENTS ADIPOCYTE HYPERTROPHY; OXIDATIVE STRESS; INSULIN; SWEETENERS; AUTOPHAGY; TRENDS;

D O I：

10.1016/j.dsx.2019.05.023

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Diabetes mellitus is the most prevalent metabolic disorder contributing to significant morbidity and mortality in humans. Many preventative and therapeutic agents have been developed for normalizing glycemic profile in patients with diabetes. In addition to various pharmacologic strategies, many non-pharmacological agents have also been suggested to improve glycemic control in patients with diabetes. Trehalose is a naturally occurring disaccharide which is not synthesized in human but is widely used in food industries. Some studies have provided evidence indicating that it can potentially modulate glucose metabolism and help to stabilize glucose homeostasis in patients with diabetes. Studies have shown that trehalose can significantly modulate insulin sensitivity via at least 7 molecular pathways leading to better control of hyperglycemia. In the current study, we concluded about possible anti-hyperglycemic effects of trehalose suggesting trehalose as a potentially potent non-pharmacological agent for the management of diabetes. (C) 2019 Diabetes India. Published by Elsevier Ltd. All rights reserved.

引用

页码：2214 / 2218

页数：5

共 55 条

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