Controlling the Cytotoxicity of CdSe Magic-Sized Quantum Dots as a Function of Surface Defect Density

被引：27
作者：
Almeida Silva, Anielle Christine [1 ]
Barbosa Silva, Marcelo Jose [2 ]
Cordero da Luz, Felipe Andres [2 ]
Silva, Danielle Pereira [2 ]
Vieira de Deus, Samantha Luara [1 ,2 ]
Dantas, Noelio Oliveira [1 ]
机构：
[1] Univ Fed Uberlandia, Inst Fis, LNMIS, BR-38400 Uberlandia, MG, Brazil
[2] Univ Fed Uberlandia, Inst Ciencias Biomed ICBIM, Lab Osteoimunol & Imunol Tumores, BR-38400 Uberlandia, MG, Brazil
来源：
NANO LETTERS | 2014年 / 14卷 / 09期
关键词：
CdSe MSQDs; Cytotoxicity; HeLa cells; methallothionein; surface defect levels; CAUSE OXIDATIVE STRESS; CLINICAL-SIGNIFICANCE; MESSENGER-RNA; CELL-DEATH; CADMIUM; METALLOTHIONEINS; NANOCRYSTALS; EXPRESSION; TOXICITY; DAMAGE;
D O I：
10.1021/nl5028028
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Quantum dots are potentially very useful as fluorescent probes in biological systems. However, they are inherently cytotoxic because of their constituents. We controlled the cytotoxicity of CdSe magic-sized quantum dots (MSQDs) as a function of surface defect density by altering selenium (Se) concentration during synthesis. Higher Se concentrations reduced the cytotoxicity of the CdSe MSQDs and diminished mRNA expression of methallothionein because of the low cadmium ions (Cd(2+)) concentration adsorbed on the surface of the MSQDs. These results agree with luminescence spectra, which show that higher Se concentrations decrease the density of surface defects. Therefore, our results describe for the first time a simple way of controlling the cytotoxicity of CdSe MSQDs and making them safer to use as fluorescence probes in biological systems.
引用
收藏
页码：5452 / 5457
页数：6
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