Proteoglycans: Potential Agents in Mammographic Density and the Associated Breast Cancer Risk

被引：19

作者：

Shawky, Michael S. ^{[1
,2
]}

Ricciardelli, Carmela ^{[3
]}

Lord, Megan ^{[4
]}

Whitelock, John ^{[4
]}

Ferro, Vito ^{[5
]}

Britt, Kara ^{[6
,7
]}

Thompson, Erik W. ^{[8
,9
,10
]}

机构：

[1] Univ Alexandria, Fac Med, Dept Head & Neck & Endocrine Surg, Alexandria, Egypt

[2] Waikato Hosp, Dept Surg, Hamilton, New Zealand

[3] Univ Adelaide, Sch Med, Robinson Res Inst, Adelaide, SA, Australia

[4] Univ New S Wales, Grad Sch Biomed Engn, Sydney, NSW, Australia

[5] Univ Queensland, Sch Chem & Mol Biosci, Brisbane, Qld, Australia

[6] Peter MacCallum Canc Ctr, Melbourne, Vic, Australia

[7] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Melbourne, Vic, Australia

[8] Queensland Univ Technol, Inst Hlth & Biomed Innovat, Brisbane, Qld 4001, Australia

[9] Queensland Univ Technol, Sch Biomed Sci, Brisbane, Qld 4001, Australia

[10] Univ Melbourne, Dept Surg, St Vincents Hosp, Melbourne, Vic, Australia

来源：

JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA | 2015年 / 20卷 / 3-4期

关键词：

Breast cancer; Mammographic density; Proteoglycans; Extracellular matrix; Syndecan; Versican; Perlecan; Glypican; Heparanase; HEPARAN-SULFATE PROTEOGLYCANS; EXTRACELLULAR-MATRIX COMPONENTS; CARCINOMA IN-SITU; ESTROGEN-RECEPTOR; DUCTAL CARCINOMA; BASEMENT-MEMBRANES; GENE-EXPRESSION; GROWTH-FACTORS; DECORIN; SYNDECAN-1;

D O I：

10.1007/s10911-015-9346-z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Although increased mammographic density (MD) has been well established as a marker for increased breast cancer (BC) risk, its pathobiology is far from understood. Altered proteoglycan (PG) composition may underpin the physical properties of MD, and may contribute to the associated increase in BC risk. Numerous studies have investigated PGs, which are a major stromal matrix component, in relation to MD and BC and reported results that are sometimes discordant. Our review summarises these results and highlights discrepancies between PG associations with BC and MD, thus serving as a guide for identifying PGs that warrant further research towards developing chemo-preventive or therapeutic agents targeting pre-invasive or invasive breast lesions, respectively.

引用

页码：121 / 131

页数：11

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