EVALUATION OF SEMIAUTOMATED MEASUREMENT OF GEOGRAPHIC ATROPHY IN AGE-RELATED MACULAR DEGENERATION BY FUNDUS AUTOFLUORESCENCE IN CLINICAL SETTING

被引:25
作者
Panthier, Christophe [1 ]
Querques, Giuseppe [1 ]
Puche, Nathalie [1 ]
Le Tien, Valerie [1 ]
Garavito, Rocio B. [1 ]
Bechet, Stephane [2 ]
Massamba, Nathalie [1 ]
Souied, Eric H. [1 ]
机构
[1] Univ Paris 12, Ctr Hosp Intercommunal Creteil, Dept Ophthalmol, Creteil, France
[2] CHI Creteil, Ctr Rech Clin, Creteil, France
来源
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES | 2014年 / 34卷 / 03期
关键词
age-related macular degeneration; fundus autofluorescence; geographic atrophy; Region Finder; scanning laser ophthalmoscope; PROGRESSION; EYE;
D O I
10.1097/01.iae.0000433986.32991.1e
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Purpose: To assess intraobserver and interobserver agreement among physicians with different degrees of clinical experience, using a novel fundus autofluorescence semiautomated software for quantification of geographic atrophy in clinical setting. Methods: Fundus autofluorescence frames (excitation: 488 nm; emission: 500-700 nm) of 29 eyes (20 patients; mean age, 79.6 +/- 6.2 years) with geographic atrophy secondary to age-related macular degeneration, and no signs of choroidal neovascularization, were analyzed using Region Finder, a semiautomated software embedded in Spectralis (Heidelberg Engineering, Heidelberg, Germany). For each study eye, semiautomated atrophy identification and quantification were independently performed, twice (in a 2-week time frame), by 3 readers with different degrees of clinical experience (2 fellows, and 1 resident). Intraobserver and interobserver agreements were assessed. Results: Mean difference in intraobserver agreement (Bland-Altman statistics) ranged from -0.17 mm(2) to 0.13 mm(2). Intraobserver agreement was excellent until the geographic atrophy threshold value of 15.72 mm(2). Variability correlated with the size of atrophy. Mean difference in interobserver agreement (Bland-Altman statistics) ranged from -0.25 mm(2) to 0.27 mm(2), with no significant difference between senior and junior readers. Multifocal lesion or foveal involvement in atrophy was not the cause of disagreement. Conclusion: Region Finder is a reliable tool for the identification and quantification of geographic atrophy in patients with age-related macular degeneration, in a clinical setting even when performed by junior reader.
引用
收藏
页码:576 / 582
页数:7
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