T594M mutation of the β-subunit of the epithelial sodium channel in Ghanaian populations from Kumasi and London and a possible association with hypertension

被引：8

作者：

Dong, YB

Plange-Rhule, J

Owusu, I

Micah, F

Eastwood, JB

Carter, ND

Saggar-Malik, AK

Cappuccio, FP

Jeffery, S

机构：

[1] St George Hosp, Sch Med, Med Genet Unit, London SW17 0RE, England

[2] St George Hosp, Sch Med, Dept Renal Med, London SW17 0RE, England

[3] St George Hosp, Sch Med, Dept Gen Practice & Primary Care, London SW17 0RE, England

[4] Komfo Anokye Teaching Hosp, Sch Med Sci, Dept Med, Kumasi, Ghana

来源：

GENETIC TESTING | 2002年 / 6卷 / 01期

关键词：

D O I：

10.1089/109065702760093942

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have tested 186 individuals from Ghana, 95 indigenous and 91 who have settled in the United Kingdom, for the presence of the T594M mutation in the beta-subunit of the epithelial sodium channel, which is associated with hypertension in black populations. The group living in Ghana had a mean age of 27 years and were normotensive, but had an increased frequency of the T allele compared to the London-based population. If this is reflected in larger studies, and the link with hypertension is maintained in the Ghanaian population, this mutation could be a significant cause of hypertension in Ghana.

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页码：63 / 65

页数：3

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