Cu-catalyzed cross-dehydrogenative coupling:: A versatile strateav for C-C bond formations via the oxidative activation of sp3 C-H bonds

被引：564
作者：
Li, Zhiping [1 ]
Bohle, D. Scott [1 ]
Li, Chao-Jun [1 ]
机构：
[1] McGill Univ, Dept Chem, Montreal, PQ H3A 2K6, Canada
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2006年 / 103卷 / 24期
关键词：
C-H activation; catalysis; Baylis-Hillman reaction; Mannich reaction; Friedel-crafts reaction;
D O I：
10.1073/pnas.0601687103
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Cu-catalyzed cross-dehydrogenative coupling (CDC) methodologies were developed based on the oxidative activation of sp(3) C-H bonds adjacent to a nitrogen atom. Various sp, sp(2), and sp(3) C-H bonds of pronucleophiles were used in the Cu-catalyzed CDC reactions. Based on these results, the mechanisms of the CDC reactions also are discussed.
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收藏
页码：8928 / 8933
页数：6
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