Age-associated declines in immune system development and function: causes, consequences, and reversal

被引：74
作者：
Dorshkind, Kenneth [1 ]
Swain, Susan [2 ]
机构：
[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA
[2] Trudeau Inst Inc, Saranac Lake, NY 12983 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 2009年 / 21卷 / 04期
关键词：
BONE-MARROW;
D O I：
10.1016/j.coi.2009.07.001
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
引用
收藏
页码：404 / 407
页数：4
相关论文
共 6 条
[1]   The ageing immune system: is it ever too old to become young again? [J].
Dorshkind, Kenneth ;
Montecino-Rodriguez, Encarnacion ;
Signer, Robert A. J. .
NATURE REVIEWS IMMUNOLOGY, 2009, 9 (01) :57-62
[2]   Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment [J].
Ju, Zhenyu ;
Jiang, Hong ;
Jaworski, Maike ;
Rathinam, Chozhavendan ;
Gompf, Anne ;
Klein, Christoph ;
Trumpp, Andreas ;
Rudolph, K. Lenhard .
NATURE MEDICINE, 2007, 13 (06) :742-747
[3]   Resveratrol and novel potent activators of SIRT1: effects on aging and age-related diseases [J].
Knutson, Mitchell D. ;
Leeuwenburgh, Christiaan .
NUTRITION REVIEWS, 2008, 66 (10) :591-596
[4]   Donor characteristics as risk factors in recipients after transplantation of bone marrow from unrelated donors: the effect of donor age [J].
Kollman, C ;
Howe, CWS ;
Anasetti, C ;
Antin, JH ;
Davies, SM ;
Filipovich, AH ;
Hegland, J ;
Kamani, N ;
Kernan, NA ;
King, R ;
Ratanatharathorn, V ;
Weisdorf, D ;
Confer, DL .
BLOOD, 2001, 98 (07) :2043-2051
[5]   Bone marrow microenvironmental changes underlie reduced RAG-mediated recombination and B cell generation in aged mice [J].
Labrie, JE ;
Sah, AP ;
Allman, DM ;
Cancro, MP ;
Gerstein, RM .
JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 200 (04) :411-423
[6]  
Steinmann G G, 1986, Curr Top Pathol, V75, P43
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