Adult Hippocampal Neurogenesis along the Dorsoventral Axis Contributes Differentially to Environmental Enrichment Combined with Voluntary Exercise in Alleviating Chronic Inflammatory Pain in Mice

被引：98

作者：

Zheng, Jie ^{[1
,2
]}

Jiang, Ying-Ying ^{[1
,2
]}

Xu, Ling-Chi ^{[1
,2
]}

Ma, Long-Yu ^{[1
,2
]}

Liu, Feng-Yu ^{[1
,2
]}

Cui, Shuang ^{[1
,2
]}

Cai, Jie ^{[1
,2
]}

Liao, Fei-Fei ^{[1
,2
]}

Wan, You ^{[1
,2
,3
]}

Yi, Ming ^{[1
,2
]}

机构：

[1] Peking Univ, Natl Hlth & Family Planning Commiss, Minist Educ, Neurosci Res Inst,Sch Basic Med Sci, Beijing 100191, Peoples R China

[2] Peking Univ, Natl Hlth & Family Planning Commiss, Minist Educ, Dept Neurobiol,Sch Basic Med Sci, Beijing 100191, Peoples R China

[3] Peking Univ, Natl Hlth & Family Planning Commiss, Minist Educ, Key Lab Neurosci, Beijing 100191, Peoples R China

来源：

JOURNAL OF NEUROSCIENCE | 2017年 / 37卷 / 15期

基金：

中国国家自然科学基金;

关键词：

adult neurogenesis; anxiety; brain-derived neurotrophic factor; chronic inflammatory pain; environmental enrichment; hippocampus; NECROSIS-FACTOR-ALPHA; NEUROPATHIC PAIN; DENTATE GYRUS; RAT HIPPOCAMPUS; PERSISTENT PAIN; NERVOUS-SYSTEM; BRAIN; DEPRESSION; SENSITIVITY; PLASTICITY;

D O I：

10.1523/JNEUROSCI.3333-16.2017

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cognitive behavioral therapy, such as environmental enrichment combined with voluntary exercise (EE-VEx), is under active investigation as an adjunct to pharmaceutical treatment for chronic pain. However, the effectiveness and underlying mechanisms of EE-VEx remain unclear. In mice with intraplantar injection of complete Freund's adjuvant, our results revealed that EE-VEx alleviated perceptual, affective, and cognitive dimensions of chronic inflammatory pain. These effects of EE-VEx on chronic pain were contingent on the occurrence of adult neurogenesis in the dentate gyrus in a functionally dissociated manner along the dorsoventral axis: neurogenesis in the ventral dentate gyrus participated in alleviating perceptual and affective components of chronic pain by EE-VEx, whereas neurogenesis in the dorsal dentate gyrus was involved in EE-VEx's cognitive-enhancing effects. Chronic inflammatory pain was accompanied by decreased levels of brain-derived neurotrophic factor (BDNF) in the dentate gyrus, which were reversed by EE-VEx. Overexpression of BDNF in the dentate gyrus mimicked the effects of EE-VEx. Our results demonstrate distinct contribution of adult hippocampal neurogenesis along the dorsoventral axis to EE-VEx's beneficial effects on different dimensions of chronic pain.

引用

页码：4145 / 4157

页数：13

共 74 条

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