Type 2 Diabetes Mellitus and Heart Failure, A Scientific Statement From the American Heart Association and Heart Failure Society of America

被引：68
作者：
Dunlay, Shannon M.
Givertz, Michael M.
Aguilar, David
Allen, Larry A.
Chan, Michael
Desai, Akshay S.
Deswal, Anita
Dickson, Victoria Vaughan
Kosiborod, Mikhail N.
Lekavich, Carolyn L.
McCoy, Rozalina G.
Mentz, Robert J.
Pina, Ileana L.
机构：
来源：
JOURNAL OF CARDIAC FAILURE | 2019年 / 25卷 / 08期
基金：
美国国家卫生研究院;
关键词：
AHA Scientific Statement; Diabetes mellitus; type; 2; Drug therapy; Heart failure; Lifestyle; Risk factors; LEFT-VENTRICULAR DYSFUNCTION; GLUCAGON-LIKE PEPTIDE-1; CARDIAC-RESYNCHRONIZATION THERAPY; QUALITY-OF-LIFE; IMPLANTABLE CARDIOVERTER-DEFIBRILLATOR; DIPEPTIDYL PEPTIDASE-4 INHIBITORS; MILD PATIENTS HOSPITALIZATION; CONVERTING ENZYME-INHIBITORS; PRESERVED EJECTION FRACTION; ASSIST DEVICE IMPLANTATION;
D O I：
10.1016/j.cardfail.2019.05.007
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Type 2 diabetes mellitus is a risk factor for incident heart failure and increases the risk of morbidity and mortality in patients with established disease. Secular trends in the prevalence of diabetes mellitus and heart failure forecast a growing burden of disease and underscore the need for effective therapeutic strategies. Recent clinical trials have demonstrated the shared pathophysiology between diabetes mellitus and heart failure, the synergistic effect of managing both conditions, and the potential for diabetes mellitus therapies to modulate the risk of heart failure outcomes. This scientific statement on diabetes mellitus and heart failure summarizes the epidemiology, pathophysiology, and impact of diabetes mellitus and its control on outcomes in heart failure; reviews the approach to pharmacological therapy and lifestyle modification in patients with diabetes mellitus and heart failure; highlights the value of multidisciplinary interventions to improve clinical outcomes in this population; and outlines priorities for future research.
引用
收藏
页码：584 / 619
页数：36
相关论文
共 277 条
[1]   Risk of hyperkalemia and combined use of spironolactone and long-term ACE inhibitor/angiotensin receptor blocker therapy in heart failure using real-life data: a population- and insurance-based cohort [J].
Abbas, Sascha ;
Ihle, Peter ;
Harder, Sebastian ;
Schubert, Ingrid .
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, 2015, 24 (04) :406-413
[2]   Metformin Use and Mortality in Ambulatory Patients With Diabetes and Heart Failure [J].
Aguilar, David ;
Chan, Wenyaw ;
Bozkurt, Biykem ;
Ramasubbu, Kumudha ;
Deswal, Anita .
CIRCULATION-HEART FAILURE, 2011, 4 (01) :53-58
[3]   Relationship of Hemoglobin A1C and Mortality in Heart Failure Patients With Diabetes [J].
Aguilar, David ;
Bozkurt, Biykem ;
Ramasubbu, Kumudha ;
Deswal, Anita .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2009, 54 (05) :422-428
[4]   Risk Factors for Adverse Outcomes by Left Ventricular Ejection Fraction in a Contemporary Heart Failure Population [J].
Allen, Larry A. ;
Magid, David J. ;
Gurwitz, Jerry H. ;
Smith, David H. ;
Goldberg, Robert J. ;
Saczynski, Jane ;
Thorp, Micah L. ;
Hsu, Grace ;
Sung, Sue Hee ;
Go, Alan S. .
CIRCULATION-HEART FAILURE, 2013, 6 (04) :635-646
[5]   Identifying Patients Hospitalized With Heart Failure at Risk for Unfavorable Future Quality of Life [J].
Allen, Larry A. ;
Gheorghiade, Mihai ;
Reid, Kimberly J. ;
Dunlay, Shannon M. ;
Chan, Paul S. ;
Hauptman, Paul J. ;
Zannad, Faiez ;
Konstam, Marvin A. ;
Spertus, John A. .
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES, 2011, 4 (04) :389-U44
[6]   Obesity Management for the Treatment of Type 2 Diabetes: Standards of Medical Care in Diabetes-2018 [J].
不详 .
DIABETES CARE, 2018, 41 :S65-S72
[7]  
American Diabetes Association, 2017, Diabetes Care, V40, pS64
[8]   Proteinuria, Chronic Kidney Disease, and the Effect of an Angiotensin Receptor Blocker in Addition to an Angiotensin-Converting Enzyme Inhibitor in Patients With Moderate to Severe Heart Failure [J].
Anand, Inder S. ;
Bishu, Kalkidan ;
Rector, Thomas S. ;
Ishani, Areef ;
Kuskowski, Michael A. ;
Cohn, Jay N. .
CIRCULATION, 2009, 120 (16) :1577-1584
[9]   Substrate-Specific Derangements in Mitochondrial Metabolism and Redox Balance in the Atrium of the Type 2 Diabetic Human Heart [J].
Anderson, Ethan J. ;
Kypson, Alan P. ;
Rodriguez, Evelio ;
Anderson, Curtis A. ;
Lehr, Eric J. ;
Neufer, P. Darrell .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2009, 54 (20) :1891-1898
[10]   Metformin treatment is associated with a low risk of mortality in diabetic patients with heart failure: a retrospective nationwide cohort study [J].
Andersson, C. ;
Olesen, J. B. ;
Hansen, P. R. ;
Weeke, P. ;
Norgaard, M. L. ;
Jorgensen, C. H. ;
Lange, T. ;
Abildstrom, S. Z. ;
Schramm, T. K. ;
Vaag, A. ;
Kober, L. ;
Torp-Pedersen, C. ;
Gislason, G. H. .
DIABETOLOGIA, 2010, 53 (12) :2546-2553
12345678910