Hypoxia and hypoxia-inducible factors in diabetes and its complications

被引：291

作者：

Catrina, Sergiu-Bogdan ^{[1
,2
,3
]}

Zheng, Xiaowei ^{[1
]}

机构：

[1] Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden

[2] Karolinska Univ Hosp, Dept Endocrinol & Diabet, Stockholm, Sweden

[3] Acad Specialist Ctr, Ctr Diabet, Stockholm, Sweden

来源：

DIABETOLOGIA | 2021年 / 64卷 / 04期

基金：

瑞典研究理事会;

关键词：

Diabetes; Diabetes complications; Diabetic foot ulcer; Diabetic nephropathy; Diabetic retinopathy; Hypoxia; Hypoxia-inducible factor; Insulin resistance; Prolyl hydroxylase inhibitor; Review; PRO582SER POLYMORPHISM; INSULIN-RESISTANCE; OXIDATIVE STRESS; GENE-EXPRESSION; HIF-1-ALPHA; FACTOR-1-ALPHA; GLUCOSE; PROTECTS; CELLS; METABOLISM;

D O I：

10.1007/s00125-021-05380-z

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hypoxia-inducible factors (HIFs) are the key regulators of oxygen homeostasis in response to hypoxia. In diabetes, multiple tissues are hypoxic but adaptive responses to hypoxia are impaired due to insufficient activation of HIF signalling, which results from inhibition of HIF-1 alpha stability and function due to hyperglycaemia and elevated fatty acid levels. In this review, we will summarise and discuss current findings about the regulation of HIF signalling in diabetes and the pathogenic roles of hypoxia and dysregulated HIF signalling in the development of diabetes and its complications. The therapeutic potential of targeting HIF signalling for the prevention and treatment of diabetes and related complications is also discussed.

引用

页码：709 / 716

页数：8

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