Efficient Synthesis of Pyrrolo [2,3-d] Pyrimidines Containing 1,4-Disubstituted-1,2,3-Triazole Derivatives

被引：0

作者：

Ruddarraju, Radhakrishnamraju ^{[1
]}

Murugulla, Adharvana Chari ^{[1
]}

Donthabakthuni, Shobha ^{[1
]}

Kotla, Ravindar ^{[1
]}

Deshmukh, Sandeep ^{[1
]}

Maroju, Ravichandar ^{[2
]}

Palle, Sadhanandam ^{[3
]}

机构：

[1] Dr MACS Biopharma Pvt Ltd, Factory Plot 79-B&C, Patancheru 502307, Medak Dist, India

[2] Mahatma Gandhi Inst Technol, Dept Phys & Chem, Hyderabad, Telangana, India

[3] Jawaharlal Nehru Technol Univ, IST, Ctr Chem Sci & Technol, Hyderabad 500085, Telangana, India

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2017年 / 54卷 / 01期

关键词：

IN-VIVO; INHIBITORS; PYRROLOPYRIMIDINE; NUCLEOSIDES; DESIGN;

D O I：

10.1002/jhet.2611

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Here, we demonstrate a simple but highly efficient method for the synthesis of multifunctionalized pyrrolo[2,3-d] pyrimidines containing 1,4-disubstituted 1,2,3-triazole derivative coupled with various amines (10a-g) and alcohol (10h) to obtain final compounds (11a-h) with reasonable to excellent yields (25% to 94%). The newly synthesized compounds were characterized by IR, (HNMR)-H-1, (CNMR)-C-13, and mass spectroscopy analysis.

引用

页码：495 / 502

页数：8

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