Dynamics and function of DNA methylation in plants

被引：1205

作者：

Zhang, Huiming ^{[1
,2
]}

Lang, Zhaobo ^{[1
,2
]}

Zhu, Jian-Kang ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Sci, Shanghai Ctr Plant Stress Biol, Shanghai, Peoples R China

[2] Chinese Acad Sci, CAS Ctr Excellence Mol Plant Sci, Shanghai, Peoples R China

[3] Purdue Univ, Dept Hort & Landscape Architecture, W Lafayette, IN 47907 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2018年 / 19卷 / 08期

关键词：

NON-CG METHYLATION; RNA-POLYMERASE IV; NONCODING RNA; HISTONE ACETYLTRANSFERASE; TRANSPOSABLE ELEMENTS; ARABIDOPSIS-THALIANA; EPIGENETIC MUTATION; DOMAIN PROTEIN; POL-IV; GLYCOSYLASE/LYASE ROS1;

D O I：

10.1038/s41580-018-0016-z

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

DNA methylation is a conserved epigenetic modification that is important for gene regulation and genome stability. Aberrant patterns of DNA methylation can lead to plant developmental abnormalities. A specific DNA methylation state is an outcome of dynamic regulation by de novo methylation, maintenance of methylation and active demethylation, which are catalysed by various enzymes that are targeted by distinct regulatory pathways. In this Review, we discuss DNA methylation in plants, including methylating and demethylating enzymes and regulatory factors, and the coordination of methylation and demethylation activities by a so-called methylstat mechanism; the functions of DNA methylation in regulating transposon silencing, gene expression and chromosome interactions; the roles of DNA methylation in plant development; and the involvement of DNA methylation in plant responses to biotic and abiotic stress conditions.

引用

页码：489 / 506

页数：18

共 241 条

[1] Role of the Arabidopsis DNA glycosylase/lyase ROS1 in active DNA demethylation [J].