Evaluation of Angiogenesis in Non-small Cell Lung Carcinoma by CD34 Immunohistochemistry

被引：25

作者：

Zhu Bing ^{[1
]}

Yang Jian-ru ^{[2
]}

Jiang Yao-quan ^{[1
]}

Chen Shi-feng ^{[1
]}

机构：

[1] Chongqing Med Univ, Affiliated Hosp 2, Dept Cardiothorac Surg, Chongqing 400010, Peoples R China

[2] 6 Hosp Handan City, Cent Lab, Handan 056000, Peoples R China

来源：

CELL BIOCHEMISTRY AND BIOPHYSICS | 2014年 / 70卷 / 01期

关键词：

Lung carcinoma; Angiogenesis; Immunohistochemistry; Microvessel density; MICROVESSEL DENSITY; TUMOR ANGIOGENESIS; CANCER; METASTASIS; SURVIVAL;

D O I：

10.1007/s12013-014-9916-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The objective of the study was to investigate angiogenesis in non-small lung cancer by measuring the expression of CD34. Immunohistochemistry was used to detect CD34 at the endothelial cell surface in 81 surgically resected non-small cell lung cancer specimens. CD34 immunohistochemistry had high specificity and sensitivity with minimal background, which enabled efficient identification of CD34-positive staining. Statistical analysis showed that increased microvessel density (MVD) was closely correlated to tumor progression as reflected by the clinical stage (P < 0.05). However, MVD was not significantly associated with lymph node metastasis and other clinical and pathological features (P > 0.05). In conclusion, microvascular density may play an important role in the development and progression of lung cancer.

引用

页码：327 / 331

页数：5

共 14 条

[1] Folkman J, 1990, JNCI-J NATL CANCER I, V3, P4, DOI DOI 10.1093/JNCI/82.1.4
[2] MICROVESSEL COUNT PREDICTS METASTATIC DISEASE AND SURVIVAL IN NON-SMALL-CELL LUNG-CANCER
FONTANINI, G
BIGINI, D
VIGNATI, S
BASOLO, F
MUSSI, A
LUCCHI, M
CHINE, S
ANGELETTI, CA
HARRIS, AL
BEVILACQUA, G
[J]. JOURNAL OF PATHOLOGY, 1995, 177 (01) : 57 - 63
[3] Gurdi A. J., 1994, JNCI-J NATL CANCER I, V86, P614
[4] RANDOMIZED TRIAL OF LOBECTOMY VERSUS LIMITED RESECTION FOR T1 N0 NON-SMALL-CELL LUNG-CANCER
HOLMES, CE
RUCKDESCHEL, JC
JOHNSTON, M
THOMAS, PA
DESLAURIERS, J
GROVER, FL
HILL, LD
FELD, R
GINSBERG, RJ
MOUNTAIN, CF
DZUIBAN, S
KIELY, M
MCKNEALLY, MF
MOORES, DWO
RAMNES, C
WAGNER, H
BUNN, P
CHU, H
DIENHART, D
HAZUKA, M
KINZIE, J
SORENSEN, J
VANCE, V
BRAUN, T
HOPEMAN, A
KANE, M
RUSS, P
WHITMAN, GJR
FALL, SM
HANSEN, DP
HENDERSON, RH
MONCRIEF, CL
PAULING, F
SIMS, J
TELL, D
WISELYCARR, S
ABERNATHY, CM
CLARK, DA
MCCROSKEY, B
MOORE, G
MOORE, F
MYERS, A
WHITE, M
BROOKS, RJ
BULL, M
JOHNSON, FB
NEIMYR, M
PAQUETTE, FR
SACCOMANNO, G
LAD, T
[J]. ANNALS OF THORACIC SURGERY, 1995, 60 (03) : 615 - 622
[5] RELATION OF NEOVASCULARIZATION TO METASTASIS OF NON-SMALL-CELL LUNG-CANCER
MACCHIARINI, P
FONTANINI, G
HARDIN, MJ
SQUARTINI, F
ANGELETTI, CA
[J]. LANCET, 1992, 340 (8812) : 145 - 146
[6] INCIDENCE OF LOCAL RECURRENCE AND 2ND PRIMARY TUMORS IN RESECTED STAGE-I LUNG-CANCER
MARTINI, N
BAINS, MS
BURT, ME
ZAKOWSKI, MF
MCCORMACK, P
RUSCH, VW
GINSBERG, RJ
[J]. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 1995, 109 (01) : 120 - 129
[7] The role of microvessel density on the survival of patients with lung cancer: a systematic review of the literature with meta-analysis
Meert, AP
Paesmans, M
Martin, B
Delmotte, P
Berghmans, T
Verdebout, JM
Lafitte, JJ
Mascaux, C
Sculier, JP
[J]. BRITISH JOURNAL OF CANCER, 2002, 87 (07) : 694 - 701
[8] Revisions in the International System for Staging Lung Cancer
Mountain, CF
[J]. CHEST, 1997, 111 (06) : 1710 - 1717
[9] Regional lymph node classification for lung cancer staging
Mountain, CF
Dresler, CM
[J]. CHEST, 1997, 111 (06) : 1718 - 1723
[10] SURVIVAL IN EARLY-STAGE NON-SMALL-CELL LUNG-CANCER
NESBITT, JC
PUTNAM, JB
WALSH, GL
ROTH, JA
MOUNTAIN, CF
[J]. ANNALS OF THORACIC SURGERY, 1995, 60 (02) : 466 - 472

← 1 2 →