The inhibitory effects of eckol and dieckol from Ecklonia stolonifera on the expression of matrix metalloproteinase-1 in human dermal fibroblasts

被引：96

作者：

Joe, Min-Jeong

Kim, Su-Nam

Choi, Hye-Young

Shin, Woon-Seob

Park, Gab-Man

Kang, Dong-Won

Kim, Yong Kee ^{[1
]}

机构：

[1] Kwandong Univ, Coll Med, Marine Biomed Res Ctr, Kangnung 210701, South Korea

[2] KIST Gangneung Inst, Kangnung 210340, South Korea

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2006年 / 29卷 / 08期

关键词：

Ecklonia stolonifera; eckol; dieckol; matrix metalloproteinase (MMP)-I; NF-kappa B; AP-1;

D O I：

10.1248/bpb.29.1735

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In order to develop new anti-photoaging agents, we examined the inhibitory effects of 29 seaweed extracts on transcriptional activities of NF-kappa B and AP-1, and MMP-1 expression. The extracts from 3 species of Alariaceae, Eisenia bicyclis, Ecklonia cava and Ecklonia stolonifera, have showed strong inhibition of both NF-kappa B and AP-1 reporter activity, which were well correlated with their abilities to inhibit MMP-1 expression. In addition, MMP-1 expression was dramatically attenuated by treatment with eckol or dieckol which were purely isolated from E. stolonifera, indicating that these compounds are active principles to inhibit MMP-1 expression in human dermal fibroblasts. Taken together, our data demonstrate the inhibitory effect of eckol and dieckol from Ecklonia species on MMP-1 expression in human dermal fibroblasts and provide a possibility to develop as an agent for the prevention and treatment of skin aging.

引用

页码：1735 / 1739

页数：5

共 31 条

[1] Green tea polyphenol epigallocatechin-3-gallate (EGCG) differentially inhibits interleukin-1β-induced expression of matrix metalloproteinase-1 and-13 in human chondrocytes [J].