Expression and localization of the omega-3 fatty acid receptor GPR120 in human term placenta

被引：19
作者：
Lager, S. [1 ]
Ramirez, V. I. [1 ]
Gaccioli, F. [1 ]
Jansson, T. [1 ]
Powell, T. L. [1 ]
机构：
[1] Univ Texas Hlth Sci Ctr San Antonio, Dept Obstet & Gynecol, Ctr Pregnancy & Newborn Res, San Antonio, TX 78229 USA
来源：
PLACENTA | 2014年 / 35卷 / 07期
基金：
瑞典研究理事会;
关键词：
Pregnancy; BMI; DHA receptor; FFAR4; O3FAR1; FREE FATTY-ACIDS; TROPHOBLAST CELLS; OBESITY; INSULIN; ACCUMULATION;
D O I：
10.1016/j.placenta.2014.04.017
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Fatty acids can function as signaling molecules, acting through receptors in the cytosol or on the cell surface. G-Protein Receptor (GPR)120 is a membrane-bound receptor mediating anti-inflammatory and insulin-sensitizing effects of the omega-3 fatty acid docohexaenoic acid (DHA). GPR120 dysfunction is associated with obesity in humans. Cellular localization of GPR120 and the influence of maternal obesity on GPR120 protein expression in the placenta are unknown. Herein we demonstrate that GPR120 is predominantly expressed in the microvillous membrane (MVM) of human placenta and that the expression level of this receptor in MVM is not altered by maternal body mass index (BMI). (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：523 / 525
页数：3
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