Molecular-Level Functional Magnetic Resonance Imaging of Dopaminergic Signaling

被引：119

作者：

Lee, Taekwan ^{[1
]}

Cai, Lili X. ^{[1
]}

Lelyveld, Victor S. ^{[1
]}

Hai, Aviad ^{[1
]}

Jasanoff, Alan ^{[1
,2
,3
]}

机构：

[1] MIT, Dept Biol Engn, Cambridge, MA 02139 USA

[2] MIT, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA

[3] MIT, Dept Nucl Sci & Engn, Cambridge, MA 02139 USA

来源：

SCIENCE | 2014年 / 344卷 / 6183期

关键词：

NUCLEUS-ACCUMBENS CORE; RAT-BRAIN; DIRECTED EVOLUTION; SHELL; SUBTERRITORIES; TRANSPORTER;

D O I：

10.1126/science.1249380

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We demonstrate a technique for mapping brain activity that combines molecular specificity and spatial coverage using a neurotransmitter sensor detectable by magnetic resonance imaging (MRI). This molecular functional MRI (fMRI) method yielded time-resolved volumetric measurements of dopamine release evoked by reward-related lateral hypothalamic brain stimulation of rats injected with the neurotransmitter sensor. Peak dopamine concentrations and release rates were observed in the anterior nucleus accumbens core. Substantial dopamine transients were also present in more caudal areas. Dopamine-release amplitudes correlated with the rostrocaudal stimulation coordinate, suggesting participation of hypothalamic circuitry in modulating dopamine responses. This work provides a foundation for development and application of quantitative molecular fMRI techniques targeted toward numerous components of neural physiology.

引用

页码：533 / 535

页数：3

共 21 条

[1] Sensitization of Rapid Dopamine Signaling in the Nucleus Accumbens Core and Shell After Repeated Cocaine in Rats [J].