Two Titanium-Catalyzed Reaction Sequences for Syntheses of Pyrroles from (E/Z)-Chloroenynes or α-Haloalkynols

被引：74

作者：

Ackermann, Lutz ^{[1
]}

Sandmann, Rene ^{[1
]}

Kaspar, Ludwig T. ^{[1
]}

机构：

[1] Univ Gottingen, Inst Organ & Biomol Chem, D-37077 Gottingen, Germany

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 09期

关键词：

REGIOSELECTIVE SYNTHESIS; EFFICIENT SYNTHESIS; C-N; INTRAMOLECULAR HYDROAMINATION; OLIGOSUBSTITUTED PYRROLES; SUBSTITUTED PYRROLES; INDOLE SYNTHESES; ALKYNES; ALKENES; ISOCYANIDES;

D O I：

10.1021/ol900522g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Titanium-catalyzed intermolecular hydroaminations of (E/Z)-chloroenynes enabled an efficient pyrrole synthesis, which set the stage for the development of a user-friendly one-pot reaction for the regioselective preparation of fully substituted pyrroles from easily accessible alpha-haloalkynols.

引用

页码：2031 / 2034

页数：4

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