Chronic Insulin Exposure does not Cause Insulin Resistance but is Associated with Chemo-resistance in Colon Cancer Cells

被引：0
作者：
Baricevic, I. [1 ]
Roberts, D. L. [1 ]
Renehan, A. G. [1 ,2 ]
机构：
[1] Paterson Inst Canc Res, Clin & Expt Pharmacol CEP Grp, Manchester M20 9BX, Lancs, England
[2] Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Inst Canc Sci, Manchester M20 4BX, Lancs, England
来源：
HORMONE AND METABOLIC RESEARCH | 2014年 / 46卷 / 02期
关键词：
BODY-MASS INDEX; GROWTH-FACTOR AXIS; OBESITY; RECEPTOR; IRS-1; TUMORIGENESIS; OXALIPLATIN; SENSITIVITY; DIAGNOSIS; SURVIVAL;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：85 / 93
页数：9
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共 43 条
[1]   Insulin receptor and cancer [J].
Belfiore, Antonino ;
Malaguarnera, Roberta .
ENDOCRINE-RELATED CANCER, 2011, 18 (04) :R125-R147
[2]   High insulin levels impair intracellular receptor trafficking in human cultured myoblasts [J].
Bertacca, Anna ;
Ciccarone, Annamaria ;
Cecchetti, Paolo ;
Vianello, Barbara ;
Laurenza, Incoronata ;
Del Prato, Stefano ;
Benzi, Luca .
DIABETES RESEARCH AND CLINICAL PRACTICE, 2007, 78 (03) :316-323
[3]  
Bilanges Benoit, 2010, Biochem J, V431, pe1, DOI 10.1042/BJ20101445
[4]   Overweight, obesity and cancer: Epidemiological evidence and proposed mechanisms [J].
Calle, EE ;
Kaaks, R .
NATURE REVIEWS CANCER, 2004, 4 (08) :579-591
[5]   Impact of Body Mass Index on Survival After Colorectal Cancer Diagnosis: The Cancer Prevention Study-II Nutrition Cohort [J].
Campbell, Peter T. ;
Newton, Christina C. ;
Dehal, Ahmed N. ;
Jacobs, Eric J. ;
Patel, Alpa V. ;
Gapstur, Susan M. .
JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (01) :42-52
[6]   Growth hormone, the insulin-like growth factor axis, insulin and cancer risk [J].
Clayton, Peter E. ;
Banerjee, Indraneel ;
Murray, Philip G. ;
Renehan, Andrew G. .
NATURE REVIEWS ENDOCRINOLOGY, 2011, 7 (01) :11-24
[7]   Obesity, type 2 diabetes, and cancer: the insulin and IGF connection [J].
Cohen, Dara Hope ;
LeRoith, Derek .
ENDOCRINE-RELATED CANCER, 2012, 19 (05) :F27-F45
[8]   Timeline - The twentieth century struggle to decipher insulin signalling [J].
Cohen, Philip .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2006, 7 (11) :867-873
[9]   Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2 [J].
Copps, K. D. ;
White, M. F. .
DIABETOLOGIA, 2012, 55 (10) :2565-2582
[10]   Colorectal cancer [J].
Cunningham, David ;
Atkin, Wendy ;
Lenz, Heinz-Josef ;
Lynch, Henry T. ;
Minsky, Bruce ;
Nordlinger, Bernard ;
Starling, Naureen .
LANCET, 2010, 375 (9719) :1030-1047
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