Biotechnologies to tackle the challenge of neoantigen identification

被引：25

作者：

Arnaud, Marion ^{[1
]}

Duchamp, Margaux ^{[2
]}

Bobisse, Sara ^{[1
]}

Renaud, Philippe ^{[2
]}

Coukos, George ^{[1
]}

Harari, Alexandre ^{[1
]}

机构：

[1] Univ Lausanne UNIL, Dept Oncol, Ludwig Inst Canc Res Lausanne, Lausanne Univ Hosp CHUV, CH-1005 Lausanne, Switzerland

[2] Ecole Polytech Fed Lausanne, Lab Microsyst 4 LMIS4, CH-1015 Lausanne, Switzerland

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2020年 / 65卷

基金：

瑞士国家科学基金会;

关键词：

T-CELL-RECEPTORS; RESPONSES; BLOCKADE; CHIP;

D O I：

10.1016/j.copbio.2019.12.014

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Among immune correlates of clinical responses, tumor-specific neoantigens took the spotlight as relevant targets for cancer immunotherapy. The implementation of pipelines for personalized cancer therapy remains challenging due to the privacy, that is patient-specificity, of neoantigens and the low-frequency of neoantigen-specific T cells in blood and tumor samples. To overcome these obstacles, recent developments in the field of biotechnology have allowed the multiplexed identification of neoepitope-specific T cells. This review addresses the pros and cons of conventional neoantigen screening methodologies and highlights the current as well as the prospective biotechnological opportunities in the field.

引用

页码：52 / 59

页数：8

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