Role of human papillomaviruses in esophageal carcinoma: an updated systematic review from 1982 to 2013

被引:2
作者
Poljak, Mario [1 ]
Kocjan, Bostjan J. [1 ]
Hosnjak, Lea [1 ]
机构
[1] Univ Ljubljana, Fac Med, Inst Microbiol & Immunol, Ljubljana 1105, Slovenia
关键词
esophageal cancer; esophageal carcinoma; etiology; HPV; human papillomaviruses; SQUAMOUS-CELL-CARCINOMA; RISK HUMAN-PAPILLOMAVIRUS; CERVICAL-CANCER; VIRUS INFECTION; GENOTYPE ATTRIBUTION; HPV INFECTION; EXPRESSION; DNA; PREVALENCE; BETAPAPILLOMAVIRUS;
D O I
10.2217/fvl.13.116
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Tobacco, alcohol and betel quid are known etiological agents of esophageal squamous cell carcinoma (ESCC). A meta-analysis in 2012 and a literature update (1982-August 2013) identified 159 studies with a total of 11,310 ESCCs tested for the presence of human papillomaviruses (HPVs). HPV DNA was present in 30.3% offESCCs, with substantial geographic differences. A recent meta-analysis of 21 case-control studies investigating the HPV-ESCC association showed that HPVs increase the risk of ESCC at least threefold. Vaccine-preventable HPV-16 and HPV-18 are the most commonly identified HPV types in ESCC in both low- and high-incidence settings. HPVs should now be seriously considered as etiological agents for at least a subset of ESCC, and more studies are needed to provide conclusive evidence that HPVs cause ESCC.
引用
收藏
页码:69 / 86
页数:18
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