Allogeneic Stem Cell Transplantation for Acute Lymphoblastic Leukemia in Adolescents and Young Adults

被引：18

作者：

Hangai, Mayumi ^{[1
,2
]}

Urayama, Kevin Y. ^{[1
,3
]}

Tanaka, Junji ^{[4
]}

Kato, Koji ^{[5
]}

Nishiwaki, Satoshi ^{[6
]}

Koh, Katsuyoshi ^{[7
]}

Noguchi, Maiko ^{[8
]}

Kato, Keisuke ^{[9
]}

Yoshida, Nao ^{[10
]}

Sato, Maho ^{[11
]}

Goto, Hiroaki ^{[12
]}

Yuza, Yuki ^{[13
]}

Hashii, Yoshiko ^{[14
]}

Atsuta, Yoshiko ^{[15
,16
]}

Mizuta, Shuichi ^{[17
]}

Kato, Motohiro ^{[18
,19
]}

机构：

[1] Natl Ctr Child Hlth & Dev, Dept Social Med, Tokyo, Japan

[2] Univ Tokyo, Dept Pediat, Tokyo, Japan

[3] St Lukes Int Univ, Grad Sch Publ Hlth, Tokyo, Japan

[4] Tokyo Womens Med Univ, Dept Hematol, Tokyo, Japan

[5] Cent Japan Cord Blood Bank, Seto, Japan

[6] Nagoya Univ Hosp, Dept Adv Med, Nagoya, Aichi, Japan

[7] Saitama Childrens Med Ctr, Dept Hematol Oncol, Saitama, Japan

[8] Natl Kyusyu Canc Ctr, Dept Pediat, Fukuoka, Fukuoka, Japan

[9] Ibaraki Childrens Hosp, Div Pediat Hematol & Oncol, Mito, Ibaraki, Japan

[10] Japanese Red Cross Nagoya First Hosp, Dept Hematol & Oncol, Childrens Med Ctr, Nagoya, Aichi, Japan

[11] Osaka Womens & Childrens Hosp, Dept Hematol Oncol, Izumi, Japan

[12] Kanagawa Childrens Med Ctr, Div Hematol Oncol, Yokohama, Kanagawa, Japan

[13] Tokyo Metropolitan Childrens Med Ctr, Dept Hematol Oncol, Fuchu, Tokyo, Japan

[14] Osaka Univ, Dept Pediat, Grad Sch Med, Suita, Osaka, Japan

[15] Japanese Data Ctr Hematopoiet Cell Transplantat, Nagoya, Aichi, Japan

[16] Nagoya Univ, Dept Healthcare Adm, Grad Sch Med, Nagoya, Aichi, Japan

[17] Kanazawa Med Univ, Dept Hematol & Immunol, Kanazawa, Ishikawa, Japan

[18] Natl Ctr Child Hlth & Dev, Childrens Canc Ctr, Tokyo, Japan

[19] Natl Ctr Child Hlth & Dev, Dept Pediat Hematol & Oncol Res, Tokyo, Japan

来源：

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | 2019年 / 25卷 / 08期

关键词：

Acute lymphoblastic leukemia; Adolescent and young adult; Hematologic stem cell transplantation;

D O I：

10.1016/j.bbmt.2019.04.014

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hematologic stem cell transplantation (HSCT) is the most potent consolidation therapy for high-risk acute lymphoblastic leukemia (ALL), but their outcomes and complications in adolescent and young adult (AYA) patients remain unclear. We compared outcomes after HSCT for ALL among children (age 1 to 9 years; n = 607), adolescents (age 10 to 19 years; n = 783), and young adults (age 20 to 29 years old, n = 603), based on Japanese nationwide registry data. The 5-year overall survival (OS) rate among AYA patients was worse than that of children, at 64% (95% confidence interval lob 60% to 68%). In the AYA, the 5-year treatment-related mortality (TRM) after HSCT was 19% (95% CI, 16% to 22%), significantly higher than that in younger patients. The most common cause of TRM in the AYA was infection. The relapse rate was not different across the 3 age groups. When focusing on older adolescents (age 15 to 19 years), there was no difference in outcomes between those treated in pediatric centers and those treated in adult centers. In conclusion, the AYA had a greater risk of nonrelapse death than younger patients, and infection was the most common cause. Further optimization is required for HSCT in AYAs with ALL. (C) 2019 American Society for Blood and Marrow Transplantation.

引用

页码：1597 / 1602

页数：6

共 14 条

[1] Introduction of Transplant Registry Unified Management Program 2 (TRUMP2): scripts for TRUMP data analyses, part I (variables other than HLA-related data)
Atsuta, Yoshiko
[J]. INTERNATIONAL JOURNAL OF HEMATOLOGY, 2016, 103 (01) : 3 - 10
[2] Allogeneic Hematopoietic Stem Cell Transplantation in Adolescent and Adult Patients with High-Risk T Cell Acute Lymphoblastic Leukemia
Bakr, Mohammad
Rasheed, Walid
Mohamed, Said Y.
Al-Mohareb, Fahad
Chaudhri, Naeem
Al-Sharif, Fahad
Al-Zahrani, Hazza
Al-Dawsari, Ghuzayel
Saleh, Abu Jafar
Nassar, Amr
Ahmed, Shad
Elghazaly, Assem
Ahmed, Syed O.
Ibrahim, Khalid
Chebbo, Wahiba
El Gohary, Ghada M.
Al Mahayni, Muhamad H.
Hussain, Fazal
Nurgat, Zubeir
Elhassan, Tusneem Ahmed
Walter, Claudia U.
Aljurf, Mahmoud
[J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2012, 18 (12) : 1897 - 1904
[3] Survival Differences between Adolescents/Young Adults and Children with B Precursor Acute Lymphoblastic Leukemia after Allogeneic Hematopoietic Cell Transplantation
Burke, Michael J.
Gossai, Nathan
Wagner, John E.
Smith, Angela R.
Bachanova, Veronika
Cao, Qing
MacMillan, Margaret L.
Stefanski, Heather S.
Weisdorf, Daniel J.
Verneris, Michael R.
[J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2013, 19 (01) : 138 - 142
[4] In adults with standard-risk acute lymphoblastic leukemia, the greatest benefit is achieved from a matched sibling allogeneic transplantation in first complete remission, and an autologous transplantation is less effective than conventional consolidation/maintenance chemotherapy in all patients: final results of the International ALL Trial (MRC UKALL XII/ECOG E2993)
Goldstone, Anthony H.
Richards, Susan M.
Lazarus, Hillard M.
Tallman, Martin S.
Buck, Georgina
Fielding, Adele K.
Burnett, Alan K.
Chopra, Raj
Wiernik, Peter H.
Foroni, Letizia
Paietta, Elisabeth
Litzow, Mark R.
Marks, David I.
Durrant, Jill
McMillan, Andrew
Franklin, Ian M.
Luger, Selina
Ciobanu, Niculae
Rowe, Jacob M.
[J]. BLOOD, 2008, 111 (04) : 1827 - 1833
[5] Rethinking Antimicrobial Prophylaxis in the Transplant Patient in the World of Emerging Resistant Organisms-Where Are We Today?
Horton, Lucy E.
Haste, Nina M.
Taplitz, Randy A.
[J]. CURRENT HEMATOLOGIC MALIGNANCY REPORTS, 2018, 13 (01) : 59 - 67
[6] Pediatric-Inspired Therapy in Adults With Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia: The GRAALL-2003 Study
Huguet, Francoise
Leguay, Thibaut
Raffoux, Emmanuel
Thomas, Xavier
Beldjord, Kheira
Delabesse, Eric
Chevallier, Patrice
Buzyn, Agnes
Delannoy, Andre
Chalandon, Yves
Vernant, Jean-Paul
Lafage-Pochitaloff, Marina
Chassevent, Agnes
Lheritier, Veronique
Macintyre, Elizabeth
Bene, Marie-Christine
Ifrah, Norbert
Dombret, Herve
[J]. JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (06) : 911 - 918
[7] Investigation of the freely available easy-to-use software 'EZR' for medical statistics
Kanda, Y.
[J]. BONE MARROW TRANSPLANTATION, 2013, 48 (03) : 452 - 458
[8] Treatment and biology of pediatric acute lymphoblastic leukemia
Kato, Motohiro
Manabe, Atsushi
[J]. PEDIATRICS INTERNATIONAL, 2018, 60 (01) : 4 - 12
[9] Adolescents and young adults with acute lymphoblastic leukemia have a better outcome when treated with pediatric-inspired regimens: Systematic review and meta-analysis
Ram, Ron
Wolach, Ofir
Vidal, Liat
Gafter-Gvili, Anat
Shpilberg, Ofer
Raanani, Pia
[J]. AMERICAN JOURNAL OF HEMATOLOGY, 2012, 87 (05) : 472 - 478
[10] Comparison of the results of the treatment of adolescents and young adults with standard-risk acute lymphoblastic leukemia with the programa espanol de tratamiento en hematologia pediatric-based protocol ALL-96
Ribera, Josep-Maria
Oriol, Albert
Sanz, Miguel-Angel
Tormo, Mar
Fernandez-Abellan, Pascual
del Potro, Eloy
Abella, Eugenia
Bueno, Javier
Parody, Ricardo
Bastida, Pilar
Grande, Carlos
Heras, Inmaculada
Bethencourt, Concepcion
Feliu, Evarist
Ortega, Juan-Jose
[J]. JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (11) : 1843 - 1849

← 1 2 →