An acetohydroxamate-coordinated oxidovanadium(V) complex derived from pyridinohydrazone ligand with urease inhibitory activity

被引：37

作者：

Li, Yanmin ^{[1
]}

Xu, Luyao ^{[1
]}

Duan, Mengmeng ^{[1
]}

Wu, Jiahui ^{[1
]}

Wang, Yinghui ^{[1
]}

Dong, Kexin ^{[1
]}

Han, Moxuan ^{[1
]}

You, Zhonglu ^{[1
]}

机构：

[1] Liaoning Normal Univ, Dept Chem & Chem Engn, Dalian 116029, Peoples R China

来源：

INORGANIC CHEMISTRY COMMUNICATIONS | 2019年 / 105卷

关键词：

Pyridinohydrazone; Acetohydroxamate; Oxidovanadium(V) complex; Crystal structure; Urease inhibition; HELICOBACTER-PYLORI UREASE; IN-VITRO; MOLECULAR DOCKING; CRYSTAL-STRUCTURES; METAL-COMPLEXES; COPPER(II); DERIVATIVES; BINDING;

D O I：

10.1016/j.inoche.2019.05.011

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A new acetohydroxamate coordinated oxidovanadium(V) complex derived from the pyridinohydrazone ligand 2'-(2-hydroxy-4-methoxybenzylidene)nicotinohydrazide (H2L), was prepared and characterized by elemental analysis, IR, UV-vis and H-1 NMR spectra, and single crystal X-ray diffraction. Thermal analysis of the complex was performed. The V atom is in octahedral coordination. The complex has remarkable inhibitory activity on Jack bean urease with IC50 value of 14.9 mu mol.L-1. The interaction mode of the complex with the urease was studied by molecular docking technique.

引用

页码：212 / 216

页数：5

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