An acetohydroxamate-coordinated oxidovanadium(V) complex derived from pyridinohydrazone ligand with urease inhibitory activity

被引：37
|
作者：
Li, Yanmin [1 ]
Xu, Luyao [1 ]
Duan, Mengmeng [1 ]
Wu, Jiahui [1 ]
Wang, Yinghui [1 ]
Dong, Kexin [1 ]
Han, Moxuan [1 ]
You, Zhonglu [1 ]
机构：
[1] Liaoning Normal Univ, Dept Chem & Chem Engn, Dalian 116029, Peoples R China
来源：
INORGANIC CHEMISTRY COMMUNICATIONS | 2019年 / 105卷
关键词：
Pyridinohydrazone; Acetohydroxamate; Oxidovanadium(V) complex; Crystal structure; Urease inhibition; HELICOBACTER-PYLORI UREASE; IN-VITRO; MOLECULAR DOCKING; CRYSTAL-STRUCTURES; METAL-COMPLEXES; COPPER(II); DERIVATIVES; BINDING;
D O I：
10.1016/j.inoche.2019.05.011
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A new acetohydroxamate coordinated oxidovanadium(V) complex derived from the pyridinohydrazone ligand 2'-(2-hydroxy-4-methoxybenzylidene)nicotinohydrazide (H2L), was prepared and characterized by elemental analysis, IR, UV-vis and H-1 NMR spectra, and single crystal X-ray diffraction. Thermal analysis of the complex was performed. The V atom is in octahedral coordination. The complex has remarkable inhibitory activity on Jack bean urease with IC50 value of 14.9 mu mol.L-1. The interaction mode of the complex with the urease was studied by molecular docking technique.
引用
收藏
页码：212 / 216
页数：5
相关论文
共 50 条
  • [1] Synthesis, crystal structures, and urease inhibition of an acetohydroxamate-coordinated oxovanadium(V) complex derived from N′-(3-bromo-2-hydroxybenzylidene)-4-methoxybenzohydrazide
    Qu, Dan
    Niu, Fang
    Zhao, Xinlu
    Yan, Ke-Xiang
    Ye, Yu-Ting
    Wang, Jia
    Zhang, Mei
    You, Zhonglu
    BIOORGANIC & MEDICINAL CHEMISTRY, 2015, 23 (09) : 1944 - 1949
  • [2] Acetohydroxamate-coordinated Oxovanadium(V) Complexes with Halide Containing Hydrazones: Synthesis, Characterization, X-ray Crystal Structures, and Antibacterial Activity
    Peng, D. L.
    RUSSIAN JOURNAL OF COORDINATION CHEMISTRY, 2020, 46 (04) : 276 - 282
  • [3] Acetohydroxamate-coordinated Oxovanadium(V) Complexes with Halide Containing Hydrazones: Synthesis, Characterization, X-ray Crystal Structures, and Antibacterial Activity
    D. L. Peng
    Russian Journal of Coordination Chemistry, 2020, 46 : 276 - 282
  • [4] Synthesis and characterization of mixed-ligand complexes using a precursor mononuclear oxidovanadium(V) complex derived from a tridentate salicylhydrazone oxime ligand
    Sutradhar, Manas
    Barman, Tannistha Roy
    Ghosh, Saktiprosad
    Drew, Michael G. B.
    JOURNAL OF MOLECULAR STRUCTURE, 2013, 1037 : 276 - 282
  • [5] Synthesis, characterization and urease inhibition of a novel acetylhydroxamate-coordinated oxovanadium(V) complex with hydrazone ligand
    Huo, Yang
    Ye, Yu-Ting
    Cheng, Xiao-Shan
    You, Zhong-Lu
    INORGANIC CHEMISTRY COMMUNICATIONS, 2014, 45 : 131 - 134
  • [6] Synthesis, crystal structure and antimicrobial activity of a novel oxidovanadium(V) complex with tridentate Schiff base ligand
    Qiu, Xiao-Yang
    Liu, Shu-Juan
    Xu, Deng-Zhu
    INORGANIC AND NANO-METAL CHEMISTRY, 2018, 48 (06) : 286 - 290
  • [7] Thiohydantoins and hydantoins derived from amino acids as potent urease inhibitors: Inhibitory activity and ligand-target interactions
    Camargo, Priscila Goes
    Fabris, Marcieli
    Tatsuta Nakamae, Matheus Yoshimitsu
    de Freitas Oliveira, Breno Germano
    da Silva Lima, Camilo Henrique
    de Fatima, Angelo
    Ferreira Bispo, Marcelle de Lima
    Macedo, Fernando, Jr.
    CHEMICO-BIOLOGICAL INTERACTIONS, 2022, 365
  • [8] Synthesis, structural characterization, encapsulation in zeolite Y and catalytic activity of an oxidovanadium(V) complex with a tribasic pentadentate ligand
    Maurya, Mannar R.
    Bisht, Manisha
    Chaudhary, Nikita
    Avecilla, Fernando
    Kumar, Umesh
    Hsu, Hua-Fen
    POLYHEDRON, 2013, 54 : 180 - 188
  • [9] Synthesis, characterization, DFT calculations and anticancer activity of a new oxidovanadium(iv) complex with a ligand derived from o-vanillin and thiophene
    Rodriguez, Maria R.
    Balsa, Lucia M.
    Del Pla, Julian
    Garcia-Tojal, Javier
    Pis-Diez, Reinaldo
    Parajon-Costa, Beatriz S.
    Leon, Ignacio E.
    Gonzalez-Baro, Ana C.
    NEW JOURNAL OF CHEMISTRY, 2019, 43 (29) : 11784 - 11794
  • [10] Six-coordinated oxidovanadium(V) complexes derived from hydrazone and pyrone ligands: synthesis, spectroscopy, and catalytic property
    Xue, Ling-Wei
    Han, Yong-Jun
    Luo, Xiao-Qiang
    INORGANIC AND NANO-METAL CHEMISTRY, 2020, 50 (08) : 654 - 660
12345