Elevated LGI1-IgG CSF index predicts worse neurological outcome

被引：42

作者：

Gadoth, Avi ^{[1
,2
]}

Zekeridou, Anastasia ^{[1
,2
]}

Klein, Christopher J. ^{[1
,2
]}

Thoreson, Colton J. ^{[2
]}

Majed, Masoud ^{[2
]}

Dubey, Divyanshu ^{[1
,2
]}

Flanagan, Eoin P. ^{[1
,2
]}

McKeon, Andrew ^{[1
,2
]}

Jenkins, Sarah M. ^{[3
]}

Lennon, Vanda A. ^{[1
,2
,4
]}

Pittock, Sean J. ^{[1
,2
]}

机构：

[1] Mayo Clin, Dept Neurol, 200 First St SW, Rochester, MN 55905 USA

[2] Mayo Clin, Lab Med & Pathol, Rochester, MN USA

[3] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA

[4] Mayo Clin, Dept Immunol, Rochester, MN USA

来源：

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY | 2018年 / 5卷 / 05期

关键词：

LEUCINE-RICH; ENCEPHALITIS; ANTIBODIES;

D O I：

10.1002/acn3.561

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

To determine whether CSF leucine-rich glioma-inactivated 1(LGI1)-IgG titer, index or IgG subclass has prognostic significance, we tested serum and CSF specimens collected concomitantly from 39 seropositive patients. LGI1-IgG index was elevated (>1) in 21 patients (54%), suggesting intrathecal synthesis. Patients with worse outcome at last follow-up (modified Rankin Scale >2) had significantly higher index (median 6.57 vs. 0.5, P=0.048) compared to those with better outcome. Higher CSF LGI1-IgG4 subclass-specific titer and index correlated with worse outcome (P<0.005 for both). These data suggest that evidence of intrathecal LGI1-IgG synthesis may correlate with neuronal injury and warrant consideration of aggressive immunotherapy.

引用

页码：646 / 650

页数：5

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