Mapping of the murine type 1 diabetes locus Idd20 by genetic interaction

被引：12
作者：
Morin, Joelle
Boitard, Christian
Vallois, David
Avner, Philip
Rogner, Ute Christine
机构：
[1] Inst Pasteur, Unite Genet Mol Murine, CNRS, URA 2578, F-75724 Paris 15, France
[2] Hop Cochin, INSERM, U561, F-75014 Paris, France
来源：
MAMMALIAN GENOME | 2006年 / 17卷 / 11期
关键词：
D O I：
10.1007/s00335-006-0076-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In the nonobese diabetes mouse, the murine type 1 diabetes susceptibility locus Idd20 interacts genetically with the diabetes resistance locus Idd19. Both Idds are located on distal mouse Chromosome 6, and previous studies on NOD.C3H congenic strains have shown that C3H alleles at Idd20 can suppress the disease-promoting effects of C3H alleles at Idd19 in both spontaneous and cyclophosphamide-induced diabetes. In this article we present the construction of novel congenic strains which, while maintaining the C3H alleles at Idd19, have allowed the candidate interval of Idd20 to be reduced from 4 to 1.8 cM. The analysis of these strains shows that Idd20 controls the progression of insulitis. Idd20 also increases the suppressive but not the pathogenic activity of splenocytes in diabetes transfer experiments. Our results suggest that the two Chromosome 6 susceptibility loci, Idd6 and Idd20, interact with the resistance locus Idd19 by regulating the activity of suppressor cells in the peripheral immune system.
引用
收藏
页码：1105 / 1112
页数：8
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