Potential ligands for cell adhesion molecules in human milk

被引:16
作者
Schwertmann, A [1 ]
Rudloff, S [1 ]
Kunz, C [1 ]
机构
[1] FORSCH INST KINDERERNAHRUNG, D-44225 DORTMUND, GERMANY
关键词
human milk; infant nutrition; cell adhesion molecules; selectins; carbohydrate ligands; EPITHELIAL-CELLS; BREAST-MILK; OLIGOSACCHARIDES; ENDOTHELIUM; INHIBITION; SELECTINS; INFANTS; MUCIN; FECES;
D O I
10.1159/000177965
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In this study, glycoproteins and oligosaccharides with sialyl Lewis a, sialyl Lewis x, Lewis x, and Lewis y epitopes were isolated by ultracentrifugation and fast-protein liquid chromatography from human milk of mothers with term or preterm infants. The identification of these epitopes on whey proteins was achieved by monoclonal antibodies and lectins after Western blotting. Lactose-derived oligosaccharides were characterized by high-performance thin-layer chromatography and high-pH anion-exchange chromatography with pulsed amperometric detection. These carbohydrate epitopes which are potential ligands for selectins are not of cellular origin but appear in the soluble fraction of milk. Here, they are present as lactose-derived oligosaccharides (molecular weight <10 kD) or bound to proteins with a high molecular weight (>100 kD). Lewis antigens might represent another category of protective nonimmunological substances in human milk with the potential to influence inflammatory processes in human milk fed infants.
引用
收藏
页码:252 / 262
页数:11
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