Emerging Roles of DNA Glycosylases and the Base Excision Repair Pathway

被引：70
|
作者：
Mullins, Elwood A. [1 ]
Rodriguez, Alyssa A. [1 ]
Bradley, Noah P. [1 ]
Eichman, Brandt F. [1 ,2 ]
机构：
[1] Vanderbilt Univ, Dept Biol Sci, Nashville, TN 37232 USA
[2] Vanderbilt Univ, Sch Med, Dept Biochem, Nashville, TN 37232 USA
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 2019年 / 44卷 / 09期
基金：
美国国家科学基金会;
关键词：
INTERSTRAND CROSS-LINKS; FANCONI-ANEMIA PATHWAY; AZINOMYCIN-B; HUMAN NEIL3; DAMAGE RECOGNITION; CRYSTAL-STRUCTURE; BACILLUS-CEREUS; SELF-RESISTANCE; MOUSE ORTHOLOG; MECHANISM;
D O I：
10.1016/j.tibs.2019.04.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The base excision repair (BER) pathway historically has been associated with maintaining genome integrity by eliminating nucleobases with small chemical modifications. In the past several years, however, BER was found to play additional roles in genome maintenance and metabolism, including sequence-specific restriction modification and repair of bulky adducts and interstrand crosslinks. Central to this expanded biological utility are specialized DNA glycosylases - enzymes that selectively excise damaged, modified, or mismatched nucleobases. In this review we discuss the newly identified roles of the BER pathway and examine the structural and mechanistic features of the DNA glycosylases that enable these functions.
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页码：765 / 781
页数：17
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