Microvascular structure and function in salt-sensitive hypertension

In many individuals with essential hypertension dietary salt can further increase blood pressure by augmentation of an already elevated total peripheral resistance. There is little information on the microvascular changes that contribute to salt-sensitive hvpertension in humans, but studies in the Dahl salt-sensitive rat leave provided some knowledge of the microcirculation in tales forth of hypertension. These studies most of which leave used intravital microscopy or isolated vessel technology, are the focus of this review. The salt-induced exacerbation of hypertension in Dahl rats is due to a uniform increase in hemodynamic resistance throughout most of the peripheral vasculature. In the spinotrapezius muscle this resistance increase is largely due to the intense constriction of proximal arterioles. The mechanisms responsible for labs increased arteriolar tone include increased responsiveness to oxygen told a loss of tonic nitric oxide (NO) availability caused by reduced endothelial NO production and/or accelerated NO degradation by reactive oxygen species. Within the last decade it has become increasingly clear that high salt intake can also lead to changes in microvascular structure and function in the absence of increased arterial pressure. This effect most also be considered when evaluating microvascular changes gild their functional consequences in salt-sensitive hvpertension.