Dendritic Integration of Sensory Evidence in Perceptual Decision-Making

被引：44

作者：

Groschner, Lukas N. ^{[1
]}

Hak, Laura Chan Wah ^{[1
]}

Bogacz, Rafal ^{[2
]}

DasGupta, Shamik ^{[1
,3
]}

Miesenbock, Gero ^{[1
]}

机构：

[1] Univ Oxford, Ctr Neural Circuits & Behav, Tinsley Bldg,Mansfield Rd, Oxford OX1 3SR, England

[2] Univ Oxford, MRC Brain Network Dynam Unit, Mansfield Rd, Oxford OX1 3TH, England

[3] Tata Inst Fundamental Res, Mumbai 400005, Maharashtra, India

来源：

CELL | 2018年 / 173卷 / 04期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

DROSOPHILA MUSHROOM BODY; CA1 PYRAMIDAL NEURONS; PARIETAL CORTEX; SIGNAL PROPAGATION; LANGUAGE DISORDER; MEMORY RETRIEVAL; NEURAL BASIS; GENE; DOPAMINE; SPEECH;

D O I：

10.1016/j.cell.2018.03.075

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Perceptual decisions require the accumulation of sensory information to a response criterion. Most accounts of how the brain performs this process of temporal integration have focused on evolving patterns of spiking activity. We report that subthreshold changes in membrane voltage can represent accumulating evidence before a alpha beta core Kenyon cells (alpha beta(c), KCs) in the mushroom bodies of fruit flies integrate odor-evoked synaptic inputs to action potential threshold at timescales matching the speed of olfactory discrimination. The forkhead box P transcription factor (FoxP) neuronal integration and behavioral decision times by controlling the abundance of the voltage-gated potassium channel Shal (K(v)4) in alpha beta(c) KC dendrites alpha beta(c) KCs thus tailor, through a particular constellation of biophysical properties, the generic process of synaptic integration to the demands of sequential sampling.

引用

页码：894 / +

页数：25

共 67 条

[61] Neuronal assemblies of the Drosophila mushroom body [J].