Preparation and Characterization of Poly(l-lactide-co-glycolide-co-ε-caprolactone) Porous Microspheres

被引:7
|
作者
Zhang, Chao [1 ]
Zhou, Zhihua [1 ,2 ,3 ]
Liu, Wenjuan [2 ]
Huang, Tianlong [4 ]
Zhao, Yanmin [1 ]
Chen, Ping [1 ]
Zhou, Ziwei [1 ]
Wang, Dan [1 ]
Yi, Meiling [1 ]
Fang, Jianjun [1 ]
机构
[1] Hunan Univ Sci & Technol, Sch Chem & Chem Engn, Dept Appl Chem, Xiangtan, Peoples R China
[2] Hunan Univ Sci & Technol, Hunan Prov Key Lab Controllable Preparat & Funct, Xiangtan, Peoples R China
[3] Hunan Univ Sci & Technol, Key Lab Theoret Organ Chem & Funct Mol, Minist Educ, Xiangtan, Peoples R China
[4] Cent South Univ, Xiangya Hosp 2, Dept Orthoped, Changsha, Peoples R China
来源
JOURNAL OF MACROMOLECULAR SCIENCE PART B-PHYSICS | 2021年 / 60卷 / 05期
关键词
gelatin; poly(l-lactide-co-glycolide-co-ε -caprolactone); porous microspheres;
D O I
10.1080/00222348.2020.1847407
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Porous microspheres have interconnecting external and internal pore structure resulting in enormous specific surface area and have drawn attention for drug delivery. In this work, poly(l-lactide-co-glycolide-co-epsilon-caprolactone) (PLLGC) porous microspheres were prepared by a combined solvent evaporation and particle leaching method using gelatin as a porogen. The effects of preparation parameters on the morphologies of the porous microspheres were studied. The resultant microspheres showed porous surfaces and a three-dimensional internal network structure with interconnecting pores. The porous microsphere size decreased with increasing stirring speed and decreasing PLLGC concentration. There were fewer micropores on the surfaces of the microspheres with increasing temperature. The number of the pores and pore size on the surface of the microspheres increased with increasing gelatin content. By appropriate control of these factors (stirring speed 300 rpm, PLLGC solution concentration 1.0 wt%, temperature 0 degrees C, and gelatin concentration 7.5 wt%), a suitable porous microsphere, with a mean diameter of 200 mu m, was prepared as a potential drug delivery agent.
引用
收藏
页码:313 / 323
页数:11
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