Evolving superantigens of Staphylococcus aureus

被引:0
作者
Ulrich, RG [1 ]
机构
[1] USA, Med Res Inst Infect Dis, Lab Mol Immunol, Ft Detrick, MD 21702 USA
来源
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY | 2000年 / 27卷 / 01期
关键词
superantigen; Staphylococcus aureus; autoimmunity; toxic-shock syndrome; virulence factor; HLA-DR; T-cell receptor;
D O I
暂无
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Staphylococcus aureus bacteria utilize an extensive array of molecular countermeasures to manipulate the defensive microenvironment of the infected host and colonize potentially any tissue. The secreted polypeptides referred to as superantigens are unique among these countermeasures, because they target the multireceptor communication between T cells and antigen-presenting cells that is fundamental to initiating pathogen-specific immune clearance. Superantigens play a critical role in toxic-shock syndrome and food poisoning, yet their function in routine infections is not well understood. While an association of superantigens with cases of human autoimmune disease seems tantalizing, convincing data are not yet available. Blocking antigen-specific T-cell recognition is the primary evolutionary driving force behind superantigen selection, whereas superantigen-specific pathologies are by-products that are apparent only under select conditions. (C) 2000 Published by Elsevier Science B.V. All rights reserved.
引用
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页码:1 / 7
页数:7
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