Macroporous and nanofibrous PLLA scaffolds reinforced with calcium phosphate-coated multiwalled carbon nanotubes

被引：13
作者：
Cai, Qing [1 ]
Mao, Jifu [1 ]
Li, Xiaoli [1 ]
Yang, Xiaoping [1 ]
机构：
[1] Beijing Univ Chem Technol, State Key Lab Organ Inorgan Composites, Beijing Lab Biomed Mat, Beijing 100029, Peoples R China
来源：
MATERIALS LETTERS | 2014年 / 128卷
基金：
中国国家自然科学基金;
关键词：
Macroporous and nanofibrous scaffold; Carbon nanotubes; Calcium phosphate; Nanocomposites; SIMULATED BODY-FLUID; BIOMINERALIZATION; POLYMER;
D O I：
10.1016/j.matlet.2014.04.164
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Scaffolds with both macro- and nanoscale structures have shown promise in tissue engineering; however, their mechanical properties are not satisfactory for load-bearing bone regeneration. In this study, calcium phosphate-coated multiwalled carbon nanotubes (MWCNTs-CaP) were developed to reinforce macroporous poly(L-lactide) (PLLA) scaffolds with nanofibrous pore walls. The scaffolds were prepared using a phase separation/particle-leaching method. One-dimensional MWCNTs-CaP were prepared via phosphorylation and mineralization. The addition of the MWCNTs-CaP did not affect the nanofibrous pore walls of the resulting PLLA scaffolds. In comparison with pure PLLA scaffolds, the compressive properties of PLLA/MWCNTs-CaP composite scaffolds were significantly improved, indicating their potential in bone regeneration applications. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码：238 / 241
页数：4
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