Cholinesterases Inhibitory Activity of 1H-benzimidazole Derivatives

被引：14

作者：

Dinparast, Leila ^{[1
]}

Zengin, Gokhan ^{[2
]}

Bahadori, Mir Babak ^{[3
]}

机构：

[1] Tabriz Univ Med Sci, Biotechnol Res Ctr, Tabriz, Iran

[2] Selcuk Univ, Sci Fac, Dept Biol, Konya, Turkey

[3] Maragheh Univ Med Sci, Med Plants Res Ctr, Maragheh, Iran

来源：

BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY | 2021年 / 11卷 / 03期

关键词：

benzimidazole; Alzheimer's disease; acetylcholinesterase; butyrylcholinesterase; BENZIMIDAZOLE DERIVATIVES; DESIGN; GLUCOSIDASE; DOCKING; AGENTS;

D O I：

10.33263/BRIAC113.1073910745

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that causes brain cells to waste away and die. The most common strategy for the treatment of AD is the inhibition of acetyl/butyrylcholinesterase (AChE and BChE) enzymes. Benzimidazole derivatives are important heterocyclic bioactive agents. In this study, in vitro inhibitory potential of 12 previously synthesized benzimidazoles was evaluated against acetyl/butyrylcholinesterases. Results showed that some derivatives have moderate AChE (IC50 = 1.01-1.19 mM) and BChE (IC50 = 1.1-1.87 mM) inhibitory activity. Findings could be helpful in the design and development of new effective anti-AD drugs with benzimidazole core.

引用

页码：10739 / 10745

页数：7

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