Folic acid-tethered poly(N-isopropylacrylamide)-phospholipid hybrid nanocarriers for targeted drug delivery

被引：9

作者：

John, Johnson V. ^{[1
]}

Jeong, Young-Il ^{[2
]}

Johnson, Renjith P. ^{[1
]}

Chung, Chung-Wook ^{[2
]}

Park, Huiju ^{[1
]}

Kang, Dae Hwan ^{[2
]}

Cho, Jin Ku ^{[3
]}

Kim, Yongjin ^{[3
]}

Kim, Il ^{[1
]}

机构：

[1] Pusan Natl Univ, BK21 PLUS Ctr Adv Chem Technol, Dept Polymer Sci & Engn, Busan 609735, South Korea

[2] Pusan Natl Univ Hosp, Biomed Res Inst, Busan 602739, South Korea

[3] Korea Inst Ind Technol, Green Proc & Mat R&D Grp, Ipjang Myeon 331822, Cheonan, South Korea

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2015年 / 3卷 / 42期

基金：

新加坡国家研究基金会;

关键词：

LIPOSOMES; RAFT; NANOPARTICLES; CONJUGATION; POLYMERS;

D O I：

10.1039/c5tb01063b

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

A series of temperature-responsive lipopolymers have been synthesized by bioconjugating poly(N-isopropylacrylamide)(n) (n = 25, 40, 60) onto three different phospholipids by the combination of reversible addition fragmentation chain transfer polymerization and azide-alkyne click reactions. To achieve the active targeting of cancer cells, folic acid (FA) has also been tethered to the resulting hybrid materials. The doxorubicin (Dox) encapsulated uniform nanocarriers (150 nm in diameter) fabricated by the self-assembly of the lipopolymers display temperature responsive controlled release. The FA receptor-mediated delivery of Dox was then assessed using KB cell lines, and the anti-cancer activity was assessed by the blocking of folic acid receptors. The FA-tethered lipopolymers showing temperature-responsiveness are advantageous for the cell-specific release of Dox, potentiating their anti-cancer activity.

引用

页码：8268 / 8278

页数：11

共 33 条

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