Beyond the semi-synthetic artemisinin: metabolic engineering of plant-derived anti-cancer drugs

被引：41

作者：

Carqueijeiro, Ines ^{[1
]}

Langley, Chloe ^{[2
]}

Grzech, Dagny ^{[2
]}

Koudounas, Konstantinos ^{[1
]}

Papon, Nicolas ^{[3
]}

O'Connor, Sarah E. ^{[2
]}

Courdavault, Vincent ^{[1
]}

机构：

[1] Univ Tours, Biomol & Biotechnol Vegetales BBV, EA 2106, Tours, France

[2] Max Planck Inst Chem Ecol, Dept Nat Prod Biosynth, Jena, Germany

[3] UNIV Brest, Grp Etude Interact Hote Pathogene GEIHP, EA 3142, SFR ICAT 4208, Angers, France

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2020年 / 65卷

基金：

欧洲研究理事会; 欧盟地平线“2020”;

关键词：

SYNTHETIC BIOLOGY; PATHWAY; YEAST; OPTIMIZATION; COLI;

D O I：

10.1016/j.copbio.2019.11.017

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The discovery and supply of plant-derived anti-cancer compounds remain challenging given their low bioavailability and structural complexity. Reconstituting the pathways of these compounds in heterologous hosts is a promising solution; however, requires the complete elucidation of the biosynthetic genes involved and extensive metabolic engineering to optimise enzyme activity and metabolic flux. This review describes the current strategies and recent advancements in the production of these valuable therapeutic compounds, and highlights plant-derived immunomodulators as an emerging class of anti-cancer agents.

引用

页码：17 / 24

页数：8

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