Endosomal compartment: Also a dock for MHC class I peptide loading

被引：4

作者：

Ma, Wenbin ^{[1
]}

Van den Eynde, Benoit J. ^{[1
]}

机构：

[1] Catholic Univ Louvain, WELBIO Walloon Excellence Life Sci & Biotechnol, de Duve Inst, Ludwig Inst Canc Res, B-1200 Brussels, Belgium

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2014年 / 44卷 / 03期

关键词：

Antigen presentation; processing; CD8(+) T cells; MHC; Vaccination; INVARIANT CHAIN; STANDARD PROTEASOME; ANTIGENIC PEPTIDES; GENETIC EXCHANGE; HLA-DR; MOLECULES; ASSOCIATION; IMMUNOPROTEASOME; EXPRESSION; EPITOPES;

D O I：

10.1002/eji.201444470

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The endosomal compartment, which contains all the components required for loading peptides onto MHC class II molecules, is classically considered to be dedicated to the loading of MHC class II but not MHC class I molecules. However, a report in this issue of the European Journal of Immunology [Eur. J. Immunol. 2014. 44: 774-784], together with other recent studies, shows that the endosomal compartment also supports efficient loading of MHC class I molecules. These results bring a new perspective on the crosstalk between the MHC class II and MHC class I antigen-processing pathways, and may inspire new ideas for the design of vaccines against viruses and tumors.

引用

页码：650 / 653

页数：4

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